Gap SANS-303: Test the efficacy of AG (centrifugation)-induced fluid shift versus other mechanical countermeasures.
Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Description
Present state of knowledge: Reversal of the headward fluid shift is hypothesized to prevent the development of SANS findings, but the magnitude and duration of the reversal needed to successfully prevent SANS findings are unknown. Artificial gravity (AG) may reverse the headward fluid shift to a greater degree than is possible using other proposed countermeasures and may be required if other mechanical countermeasures are found to be insufficient for the prevention of SANS. In addition, creating a dose-response curve of G-level versus degree of fluid shift may help understand the magnitude and duration needed for other mechanical countermeasures.

Research approach: Evaluate the effectiveness of different levels of centrifugation compared with outcomes from the mechanical and exercise interventions developed under gap SANS-301 and validated under gap SANS-302. Studies will be pursued in both bed rested subjects (chronic intermittent centrifugation of various durations and G-levels) as well as in more acute exposures of ambulatory subjects.
Target for Closure
1) Determination whether AG is more efficient than other mechanical countermeasures, such as, for example, LBNP. 2) Understanding whether creation of hydrostatic gradients is necessary for mitigating SANS efficiently.
Mappings
Risk Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
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