Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Description
Present state of knowledge: At the time of this writing, countermeasures to prevent SANS findings have not yet been tested during spaceflight or strict head-down tilt bed rest. The role of chronic mildly elevated intracranial pressure (ICP) in the development of SANS findings may differ between spaceflight and strict head-down tilt bed rest. If ICP does contribute to SANS, pharmaceuticals targeting lowering of ICP may be considered. If genetic SNPs and resulting biochemistry are determined to contribute to the development of SANS findings, supplemental vitamins may be considered. If exercise is deemed to contribute or limit the development of SANS findings, modifications to the type, duration, or timing of exercise can be considered.

Research approach: Individual testing of non-mechanical countermeasures in a strict head-down tilt bed rest analog (e.g. pharmaceuticals including supra-physiologic vitamin B, exercise, other).
Target for Closure
Ground validation of the effectiveness of non-mechanical countermeasures that can be used alone or in combination with mechanical countermeasures.
Mappings
Risk Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
You are here! Gap SANS-401: Test non-mechanical countermeasures in a strict bed rest analog.
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Multi-Disciplinary Research Plans

Documentation:
No Documentation Available