Last Published:
07/30/20 02:45:13 PM (Central)
Responsible Element: Human Factors and Behavioral Performance (HFBP)
Status: Open
Crewmembers will live and work within the confines of a spacecraft, rovers, and surface habitats for extended periods of time. Past and Current ISS operations of up to 6-month spaceflight missions and available environmental characteristics (e.g., large habitable space, IP Phone, views of Earth) have enabled crewmembers to live in space without major behavioral health incidents. Conversely, future long duration missions (e.g., Mars) , will expose crewmembers to prolonged confinement and extreme environmental monotony of a mission of up to 30 months, five times the length of current ISS increments. These environments will result in increased autonomy and isolation from Earth which will impose a strain upon crews of historical significance. Environmental psychology research has shown that humans have evolved to function best in Earth-like environments. There is significant disparity between Earth and vehicle/habitat environments required for long-duration space exploration. Human Research Program (HRP) research has identified the potential environmental stressors in the long duration spaceflight environment (e.g., isolation, confinement, sensory deprivation) and the risks these stressors pose for psychological and behavioral health. Environmental psychology research, spaceflight analog research and anecdotal spaceflight evidence show that risks posed by environmental stressors can be mitigated by modifying the vehicle environment (e.g., introduction of novel stimuli, greenhouses, virtual reality, etc.). Thus, these habitat/vehicle environments also offer protection from the hazards of spaceflight and can serve to mitigate the negative psychological and behavioral effects of environmental stressors (e.g., isolation, confinement, reduced sensory stimulation) likely to be experienced during long-duration spaceflight. HRP funded research has sought to identify and validate habitat environmental specifications, countermeasures, and operational regimens for using light to prevent and mitigate health and performance decrements due to sleep, circadian, and neurobehavioral disruption, for flight, surface, and ground crews, during all phases of spaceflight operations. Diet and nutrition offer key modifiable targets for the prevention of psychiatric disorders associated with BMed risk. For example, multiple lines of research indicate that diets rich in phytochemicals (e.g., polyphenols) know for their antioxidant and anti-inflammatory properties can mitigate increases in vascular inflammation increases due to aging, stress, GCR exposure, etc. Growing evidence indicates a relationship between nutrition deficiencies, diet quality and mental health and for the efficacy and use of nutritional supplements to address deficiencies or as augmentation to other therapies. Research results from CBS Nutritional Datamining and CBS biomarker identification tasks have helped identify the biological pathways that mediate the observed relationships between diet, nutrition and behavioral health, to determine how the immune system, oxidative biology, brain plasticity, and the microbiome-gut-brain axis may serve as key targets for nutritional interventions. In addition, results have helped inform the optimal use of light (timing, duration, intensity, and spectral power distribution) as a countermeasure. Findings from these studies have resulted in recommendations for the ISS vehicle, long-duration analogs, and provided the justification for an evidence-based flexible lighting system that was implemented on ISS starting in 2015. Planned research is ongoing to validate recommended protocols for this lighting system. On-board system monitoring systems (cf., “smart habitats”) may activate countermeasures (e.g., by noting performance changes or other biomarkers) and then help align biological and medical interventions like exercise and conditioning, as well as dietary or nutritional supplements. Biological and medical interventions are distinguished from physical or mission design countermeasures such as shielding, time in solar cycle, or mission duration (e.g. transit times, surface stays) as they are addressed by other Risks.
Approach:
There is a need for validated countermeasures to promote individual behavioral health and performance during exploration missions. The countermeasures identified will need to consider anticipated mission constraints, such as individualized protocols for using light, identifying efficient uses of light (e.g., less power, crew time), and how these factors relate to the circadian, sleep, and photobiology communities to better understand what other agencies’ investigations are funding and how the science funded externally can inform NASA efforts. This gap serves to provide the countermeasures necessary to support crew behavioral health (dependent on information obtained from addressing BMed Gaps 1, 2, 3, and 4). Countermeasures developed will address the pre-, during-, and post-mission phases of exploration missions. Solicitations will build on systematic reviews that help identify available versus needed information, with datamining efforts to help identify threats and promoters baselining for Earth-levels, with current countermeasures and readiness levels of research deliverables (tools and technologies). Leverage previous and ongoing research in areas of HSIA (Habitat, MPTASK, HCI), sleep, and CBS to identify habitat/environmental contributions to cognitive performance, stress-reduction, and manipulations of internal spaceflight systems to decrease risk of adverse cognitive or behavioral conditions (to include Team functioning and social team interactions). Report on critical spaceflight habitat/environmental (e.g., schedules, lighting properties) contributions; research and spaceflight results used to contribute to validation of countermeasures and standards to maintain individual cognitive, behavioral, or Team functioning, psychosocial health, and team task performance in LDSE. The implementation of countermeasures use changes in biomarkers (e.g., operationally-relevant performance measures) and other biomarker research to identify CNS/cognitive/behavioral performance changes and their magnitude, using near-term research to help set the course for effective countermeasures approaches through establishment of appropriate indexed biomarkers and model systems for use in selection and validation of candidate standard measures for monitoring. We will solicit studies to develop and validate countermeasures to fill this gap. These countermeasures will be validated in high fidelity exploration analogs and ultimately ISS. Periodic tech watches will ensure that the most advanced state-of-the-art technology is in use.
Metrics for Interim Progress:
(1) Gap focused research will identify the environmental stressors on psychological health in long-duration spaceflight and will identify and/or develop methods to assess effects of environmental modifications in the context of long duration habitation.
(2) Research that identifies and validates methods to use habitats to modify the spaceflight environment to mitigate the identified risks to behavioral health.
(3) Conduct laboratory investigations evaluating the effect of varying light sources on sleep, circadian rhythms, and performance.
(4) Develop initial protocols for testing the use of lighting protocols and other countermeasures on ISS (in-house).
(5) Capture ‘lessons learned’ from lighting countermeasures in space and finalize research aboard ISS to validate lighting protocols with ISS flexible lighting system that started in 2015, assessing lighting protocol effects on CNS/cognitive/behavioral performance through biomarkers.
(6) Conduct Habitat, Lighting, and Fatigue measures monitoring and countermeasures Technical Information Meeting to further define needed research & technology development for light in exploration class vehicles/habitats.
(7) Evaluate neurobehavioral effects of habitat and lighting systems in laboratory & analog research to further the use of light as an operationally-relevant behavioral health and performance countermeasure for long-duration exploration missions.
(8) Validation of the acceptability and effectiveness of countermeasure protocols for multiple, intelligent system, habitat activities, for use in both monitoring and providing “performance assist” and/or social support, during long-duration missions.
(9) Finalize predictive models that integrate lighting properties (intensity, duration, timing) to also include spectral power distribution and integrate models into on-board execution/decision-support systems.
(10) Updated and validated information provided to NASA medical operations and habitat designers regarding new evidence and enhanced lighting requirements that can optimize effectiveness and minimize crew resource requirements.
(11) Updated requirements and clinical guidelines, as appropriate, for using light as a countermeasure for sleep loss, circadian misalignment, and performance (and a clinical countermeasure for behavioral health).
Closure of this gap will enable us to make recommendations for modifying the habitat/vehicle environment to best maintain and promote cognitive and behavioral health among crewmembers.
An identified set of validated lighting countermeasure regimens that integrate lighting properties (timing, duration, intensity and spectral power distribution) to provide:
(1) Individualized operational protocols that optimize countermeasure effectiveness.
(2) Hardware specifications for future vehicles that enable a flexible lighting system for autonomous, long duration and/or distance exploration missions.
Validated set of psychosocial support countermeasures targeting key indicators of CNS/cognitive/behavioral operationally-relevant performance that maintains individual cognitive and behavioral health and performance. These countermeasures should be targeted to pre-mission preparation, in-flight adaptation and functional readiness, and post-mission transition/rehabilitation.
(1) Identified set of psychosocial support countermeasures targeting key indicators to maintain behavioral health and performance.
(2) Identification of indexed metrics to monitor therapeutic efficacy for acute, in-mission, and post-mission CNS/cognitive/behavioral operationally-relevant effects due to mission-relevant exposures to spaceflight hazards (e.g., space radiation, isolation, altered gravity).
(3) Identification and validation of candidate countermeasures modulating adverse outcome pathways associated with integrated risks.
(4) Verified and validated countermeasures in ground-based analogs with astronaut-like subjects.
(5) Identified and validated methods for modifying the habitat/vehicle environment to address environmental stressors and mitigate cognitive and behavioral health risks.
(6) Development of guidelines and standards for implementation of these modifications based on available information related to exploration mission scenarios.
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BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
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Active
Task Book:
Entry
Principal Investigator:
Dorneich, Michael
Short Title:
Adaptive Stress Training
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Traditional emergency training practices are focused on performance outcomes, research into countermeasures should investigate stress-training techniques for acute stress in life-threatening situations to prevent adverse behavior and performance degradation. Recent advances in virtual reality (VR) environments provide the capability to simulate stressors over multiple sessions in a realistic task setting, until realistic stress levels are achieved. A virtual reality training system that is able to adapt based on the crew member's stress response may help foster resilience. By measuring participant's physiological and performance metrics, the adaptive system would allow graduated exposure of stress levels within a suitable biometric and performance ranges. Activating the stress response, while simultaneously assuring the crew member is not overwhelmed, may facilitate inoculation to the stress. Further, the automated training would be beneficial during long duration missions where ground support and training resources are limited or unavailable. This research aims at measuring physiological stress response and in-training performance, while evaluating adaptation rules and triggers. By using stress training to familiarize and prepare crew members for future stressors, a reduced state of anxiety and increased cognitive resources enabling enhanced performance are expected. Aims include:
1. Identify components and principles that contribute to the stress in a microgravity environment;
2. Evaluate formal objective methods to measure and adapt for baseline chronic and acute stress, in-training performance, psychological stress response, lapse in judgment, and other errors during the adaptive stress training;
3. Develop a prototype for graduated stress training by evaluating adaptation rules, triggers, other state assessment in combination with biometric feedback;
4. Conduct a proof-of-concept of the training for hazardous conditions through implementation of the training on emergency procedures for the NASA International Space Station (ISS) with subsequent testing of the training in a full-scale virtual-reality ISS’ simulations; and
5. Establish guidelines for implementation of the graduated stress.
Category:
Countermeasure
Subcategory:
Protocol
Description:
(1) A final report will document the training developed, with recommendations for future R&D efforts to enhance the training design to close the NASA HRP gap.
(2) Guidelines for implementing the stress training developed.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Countermeasure
Subcategory:
Prototype Hardware or Software
Description:
(3) Software for testing emergency procedures in a spaceflight simulation using a Virtual Reality Head Mounted Display (HMD).
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Seidler, Rachel
Short Title:
AG HDBR - Neurocognitive Declines CM
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
A recently completed 70-day 6° head down tilt bed rest study examined a range of brain structural, brain functional, sensorimotor and cognitive metrics as outcome measures. Here, we select those that are sensitive to this spaceflight analog environment as outcome metrics for the following aims:
Aim 1) Determine whether 30 minutes per day of supine centrifugation +1Gz at the heart is effective at mitigating declines in brain structure, brain function, sensorimotor and cognitive performance induced by 60 days of 6° head down tilt bed rest in comparison to a control group that is not exposed to AG.
Aim 2) Determine whether centrifugation is more effective and better tolerated as a countermeasure when it is delivered continuously for 30 minutes or in six, five minute sessions separated by breaks of five minutes each.
Aim 3) Identify predictors of individual differences in bed rest and AG responses. We will examine whether pre bed rest measures of brain structure, brain function, and genotype for a few targeted single nucleotide polymorphisms (snps, COMT, DRD2, BDNF, alpha2-adrenergic receptor gene) are predictive of changes in sensory, motor, and cognitive function occurring in association with bed rest, and whether they also predict AG tolerance. We will combine data collected here with those we are acquiring in two ongoing NSBRI funded “predictors” studies to increase our predictive power.
Ground Analog Resources
| Ground-Based Flight Analogs
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Bedrest [e.g., envihab, other bedrest facilities]
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| Number of Subjects
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24
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Category:
Study Results
Subcategory:
Customer Requested Study or Analysis
Description:
A report of the data on the role of artificial gravity on mitigating changes in the brain.
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Smith, Scott
Short Title:
CBS BioNutritional CMs Data Mining (Smith)
Responsible HRP Element:
Human Factors and Behavioral Performance
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Collaborating Org(s):
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| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
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Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
1. Complete a systematic review of the literature to describe the interrelationship of nutrition (and specific nutrients) with CBS systems and risks. Identify potential nutritional countermeasures of relevance to the CBS systems and risks, focusing on how these countermeasures may influence performance outcomes.
a. Development of a comprehensive database of relevant research that allows for an assessment of the methodological quality of included studies.
b. Summarize the extent, range, and nature of nutritional countermeasures that potentially mitigate the individual and synergistic impacts of the three CBS risks.
2. Summarize relevant research findings in order to provide a scientifically plausible rationale for an integrated risk mitigation approach using nutritional countermeasures while addressing the implications for these countermeasures in the context of missionrelated factors (e.g., immune system alterations, food systems) related to crew health and operational performance.
a. Identify research conducted with animals to identify plausible approaches for use of animal models in the identification and validation of nutritional countermeasures for use in the CBS Integrated Research Plan.
3. Identify biomarkers associated with nutrition and nutritional countermeasures and their relevance to a) structural and functional changes to brain, b) associated dose-response
effects related to physiological changes, and/or c) real-time performance outcomes.
4. Use results of this literature-based research to identify gaps in knowledge related to a) potential synergistic effects of deep space travel (e.g., impacts of isolation and confinement and altered gravity, and radiation effects), b) potential use of CMs to prevent or intervene, and c) potential biomarkers for both human spaceflight and translational models. In particular, identify research gaps in the existing literature related to nutritional CMs as they relate to:
- Mechanisms
- Pathways
- Order effects validation
- Biomarkers
- Potential interactions with other countermeasures
- development/refinement of standards
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
This project is focused on nutrition, and seeks to compile a review of existing literature relating nutrition and the CBS risks. Specifically, this review will:
1. identify nutrition research related to an integrated risk posed by radiation, isolation, confinement, and the sensorimotor adaptations of altered gravity
2. identify the utility of nutrient (and/or related metabolite) biomarkers in assessing this risk.
3. identify potential benefits of nutrient countermeasures for prevention and/or
intervention to ensure sustained crew health and performance
4. identify plausible biochemical pathways that account for the effectiveness of the countermeasures
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Ronca, April
Short Title:
CBS VNSCOR #2: Effects of GCRsim/HU/ICE on Immune, Performance with Dietary CM Dev (Ronca)
Responsible HRP Element:
Human Factors and Behavioral Performance
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Collaborating Org(s):
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| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
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Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
The overall goal is to minimize risks in both male and female astronauts that are associated with long-term, deep space missions. This will be achieved to generate research results on biomarkers, brain morphology and function, performance pathways, and functional behavioral performance impairments, necessary inputs for computational human health risk models of combined space exposures. The successful completion of this work will provide a clear understanding of synergistic interactions between space environment factors in relation to crew health and performance during extended missions beyond the Van Allen belts.
Aim 1: Determine dose dependence of acute ‘Five-Ion GCR Simulation’ exposure for immune, brain and behavioral performance responses in crew age-matched adult male and female mice.
Aim 2: Determine effects of acute ‘Five-Ion GCR Simulation’ exposure singly and in combination with simulated microgravity and social isolation, on immune and nervous system responses in crew age-matched male and female mice mimicking deep space missions.
Aim 3: Determine efficacy of the dietary antioxidant, Nicotinamide Mononucleotide (NMN) in reversing immune, brain and behavioral/cognitive performance effects after acute ‘Five-Ion GCR Simulation’ exposure in socially isolated, IR and simulated microgravity exposed male and female mice, mimicking deep space missions.
Category:
Subcategory:
Description:
Fundamental questions addressed in this project examine mouse sex differences in response to major environmental factors associated with deep space:
(1) Does exposure to IR, either singly and in combination with simulated microgravity and social isolation, result in an elevation of brain reactive oxygen species (ROS), immune dysfunction, altered morphology and function in brain areas related to cognition and behavior?
(2) What is the preferred reference dose,using the Simplified Five-ion GCR Simulation at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratories (BNL), exposures that will allow for studies of both increased and decreased effects confirming combinatorial effects with other deep space factors (i.e., microgravity and social isolation)?
(3) Can immune and inflammatory markers serve as biomarkers for CNS structural and functional changes?
(4) What is the time course relative to IR, HU and social isolation for emergence of immune, brain, and performance measures?
(5) Do the observed CNS alterations lead to behavioral and cognitive impairments?
(6)What Brain Performance Pathways are implicated in HU and IR singly and in combination?
(7) Can administration of the dietary antioxidant, nicotinamide mononucleotide (NMN), a key intermediate in nicotinamide adenine dinucleotide (NAD+) biosynthesis, ameliorate these changes?
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Simpson, Richard
Short Title:
Cognitive and Immune Function Using Guided Imagery
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Given NASA's plans related to exercise for exploration mission, this study aims to address the following:
1) Primary research questions:
- Will planned exercise regimens and proposed types of exercise and equipment be sufficient to maintain behavioral health of individuals during LDEMs?
- Given the limited exercise options for future spacecraft vehicles, what behavioral regimens, strategies, techniques (e.g. mindfulness training) are needed to augment exercise protocols to maintain the astronaut’s motivation to exercise, promote behavioral adaptability and stress tolerance, and ensure continued self-care for crews during LDEMs?
2) Secondary research questions:
- Given the restricted volume of future LDEM vehicles, what enhancements to the environment can support continued engagement and satisfaction for individual crewmembers who must comply with a limited exercise option?
- As a result of study findings, should existing protocols be modified? If so, how?
Ground Analog Resources
| Ground-Based Flight Analogs
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Controlled Research Analog, Short Duration (2 months or less) – isolated and confined with spaceflight mission scenario [e.g., HERA, NEEMO], TBD
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| Number of Subjects
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48
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Category:
Countermeasure
Subcategory:
Protocol
Description:
Report on study results that addresses primary research questions, and includes evidence-based countermeasure recommendations for the following:
- Specific behavioral health enhancements and protocols (e.g., mindfulness, breathing, postural poses, stretch/strengthen venues to improve exercise compliance and effectiveness, with an emphasis on wellbeing).
- Protocols to enhance behavioral health outcomes needed to perform mission critical tasks
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Lockley, Steven
Short Title:
Exploration Lighting Protocols
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
The
overall goal of this project is to study how a programmable solid state
lighting system would be used operationally to improve sleep, enhance alertness
and performance, maintain optimal circadian entrainment, and readapt circadian
phase if the circadian misalignment occurs, in a high fidelity simulation of
the International Space Station (ISS) lighting environment, such as the Human
Exploration Research Analog (HERA). The
HERA has been fitted with programmable LED lighting that is representative of
the new solid state light assemblies (SSLAs) to be installed on the ISS. The new SSLAs
incorporate three pre-determined settings to address different operational
needs: 1) white light for general vision; 2) blue-enriched high intensity white
light to enhance alertness and circadian adaptation; 3) blue-depleted low
intensity white light to minimize alertness prior to sleep. A Dynamic Lighting
Schedule (DLS) has been developed to determine when each of these three settings will be used
to optimize lighting to improve alertness and performance, reset circadian
rhythms and enhance sleep, while maintaining vision. This project will apply the DLS in the HERA as
the next step in examining the feasibility and efficacy of the SSLA system, and
to provide the testing necessary to finalize the operational procedures for
in-flight testing of the new lights aboard ISS.
The specific aims of this study are:
In a
series of 30-day 2016 HERA Campaign missions, conduct randomized crossover
within-subject clinical trials to test the hypotheses that deployment of the DLS,
as compared to deployment of a standard, static lighting schedule, and while
also maintaining acceptable visual performance and color discrimination for
operational tasks, will:
i)
significantly improve polysomnographic and subjective measures of sleep
latency, sleep quality and sleep efficiency;
ii)
significantly improve cognitive performance, subjective alertness and mood, and
objective EEG correlates of alertness (suppression of EEG-derived delta-theta
activity [0.5-5.5 Hz]) and enhancement of EEG-derived high-alpha activity
[10.5-12 Hz]);
iii)
significantly increase the rate of circadian adaptation, as measured using the
circadian rhythm of melatonin and its metabolites before and after the shift.
The results of this investigation will yield knowledge needed for implementing a light countermeasure in the operational environment (specifically, ISS) as well as laying the ground work for testing the effectiveness, feasibility and acceptability of alternative protocols (e.g., pulsing) for Exploration vehicles.
Ground Analog Resources
| Ground-Based Flight Analogs
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Controlled Research Analog, Short Duration (2 months or less) – isolated and confined with spaceflight mission scenario [e.g., HERA, NEEMO]
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| Number of Subjects
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16
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Category:
Countermeasure
Subcategory:
Protocol
Description:
A report documenting recommendations for testing and implementing a flexible lighting schedule on ISS; recommendations for future research using alternative lighting protocols (e.g. pulsing) for Exploration; results regarding the effectiveness and acceptability of ambient light exposure as a physiological countermeasure in-flight.
Mitigates risk by providing a countermeasure for circadian entrainment/shifting, sleep, alertness and performance.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Countermeasure
Subcategory:
Protocol
Description:
Requirements for a flexible lighting system on future spaceflight vehicles to ensure light as a physiological countermeasure inflight. Mitigates risk by providing a countermeasure for circadian entrainment/shifting, sleep, alertness and performance.
Internal Customers:
None
External Customers:
Future Exploration Program
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Countermeasure
Subcategory:
Protocol
Description:
Protocols/operational regimens that minimize human resource constraints while enabling light to serve as a countermeasure for maintaining circadian alignment. Mitigates risk by providing a countermeasure for circadian entrainment/shifting, sleep, alertness and performance.
Internal Customers:
None
External Customers:
Med Ops - Medical Operations
Is a Customer-Supplier Agreement (CSA) Required?
Yes
Task Book:
Entry Unavailable
Principal Investigator:
Boerma, Marjan
Short Title:
Gamma-tocotrienol as a Radiation Countermeasure
Responsible HRP Element:
Space Radiation
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Specific Aim 1: Determine the efficacy of γ-tocotrienol as a countermeasure against mixed
charged particle radiation-induced carcinogenesis.
Specific Aim 2: Determine the effects of γ-tocotrienol on mixed charged particle
radiation-induced degenerative effects on the central nervous system.
Specific Aim 3: Determine the effects of γ-tocotrienol on mixed charged particle
radiation-induced degenerative effects on the cardiovascular system.
Category:
Countermeasure
Subcategory:
Clinical Procedure/Prescription
Description:
The proposed studies will address the Gaps Cancer 08, Degen - 6, and CNS - 4 by providing
a systematic analysis of γ-tocotrienol as a safe oral countermeasure against mixed charged
particle-induced carcinogenesis and degenerative effects in the heart, brain and vasculature (see
also 4. Map to Human Research Roadmap). The Countermeasure Readiness Level (CRL) at the
start of the project will be 4 (“Formulation of countermeasure concept based on understanding of
phenomenon”), and at the completion of the study will be 5 (“Proof of concept testing and initial
demonstration of feasibility and efficacy”). Since γ-tocotrienol is being evaluated in clinical
trials of radiation therapy, and its safety profile is high, we anticipate that the CRL can be
advanced quickly into human space flight conditions once efficacy against high-energy charged
particle irradiation is documented in animal models. This will also be one of the first studies to
provide a systematic analysis of carcinogenesis and degenerative tissue effects after exposure to
a mixed ion beam. Although hind limb unloading to model fluid shifts from exposure to
microgravity is not part of this proposal, we have experience with this model and can test γ-
tocotrienol in a combined radiation and hind limb unloading model in the future.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Slaba, Tony
Short Title:
GSAM
Responsible HRP Element:
Space Radiation
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
GSAM project provides delivery scheme of low and high LET particles to best simulate 600/900 day Mars missions within facility and animal constraints.
- Studies required to inform countermeasure testing and validation
- Fluence based versus acute exposures to simulate space radiation
GSAM (GCR Simulation and Mitigation) research objectives:
Aim 1: Design and implement Hybrid Shield Concept to simulate GCR environment at NSRL to include production of secondaries and correlated multiplicities found in space
Aim 2: Validate ground simulation of dose rate including fractionation and time course delivery of particles to simulate low dose chronic exposures in space.
Aim 3: Evaluation of dose delivery scheme with biological timescales to inform chronic studies.
Aim 4: Expand design and implement Mars surface simulation at NSRL to include mixed field environment found on Mars surface.
Category:
Technology or Tool
Subcategory:
Computational Models or Simulations
Description:
Multi-species hybrid simulator design inclusive of secondary particle production; Concept of biophysics operations for dose and dose rate delivery at NSRL for free space and Mars mission scenarios.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Roma, Peter
Short Title:
HFBP Exploration Measures for LDMs
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
This task will allow HRP to establish, evaluate, and manage a common set of measures for use in spaceflight and analog research to: develop baselines, systematically characterize risk likelihood and consequences, and assess effectiveness of countermeasures that work for human factors and behavioral performance risk factors. This task will provide “standard measures” as the foundation to achieve consistent research measures for data-sharing in HERA and to meet the highly constrained, operationally-focused data gathering and analysis that allows for greater consistency in the research methods that are very specific to NASA HRP standard measures development. Additionally, the set of BHP standardized measures in the HERA analog reflects the more operational nature of the measures while allowing the multiple and frequent internal and external collaborations required to execute this study.
The study aims to:
1. Provide a set of BHP standard measurements for investigators to use in proposed projects.
2. Enable comparison of multiple missions across spaceflight analog campaigns to quantify risk using reliable metric-based data.
3. Provide database for data-mining and integrative modeling and increase research data quality and transfer to LSDA.
This task will contribute to gap closure by facilitating all tasks using the HERA analog in the BMed, Sleep, and Team risk areas and by testing measures and monitoring tools for the Long Duration Mission Transit.
Ground Analog Resources
| Ground-Based Flight Analogs
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Controlled Research Analog, Short Duration (2 months or less) – isolated and confined with spaceflight mission scenario [e.g., HERA, NEEMO]
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| Number of Subjects
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32
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Category:
Technology or Tool
Subcategory:
Informatics
Description:
Standardized data across the BMed, Team, and Sleep risks for HERA campaigns to be deposited into the LSDA and shared with other HERA Investigators.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Roma, Peter
Short Title:
HFBP Exploration Measures in HERA for Mars
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
This will allow HRP to establish, evaluate, and manage a common set of measures for use in spaceflight and analog research to: develop baselines, systematically characterize risk likelihood and consequences, and assess effectiveness of countermeasures that work for human factors and behavioral performance risk factors. This task will provide “standard measures” as the foundation to achieve consistent research measures for data-sharing in HERA and to meet the highly constrained, operationally-focused data gathering and analysis that allows for greater consistency in the research methods that are very specific to NASA HRP standard measures development. Additionally, the set of HFBP standardized measures in the HERA analog reflects the more operational nature of the measures while allowing the multiple and frequent internal and external collaborations required to execute this study.
This study aims to:
1. Provide a set of HFBP standard measurements for investigators to use in proposed projects.
2. Enable comparison of multiple missions across spaceflight analog campaigns to quantify risk using reliable metric-based data.
3. Provide database for data-mining and integrative modeling and increase research data quality and transfer to LSDA.
This task will contribute to gap closure by facilitating tasks using the HERA analog in the BMed, Sleep, and Team risk areas and by testing measures and monitoring tools for Surface Operations.
Ground Analog Resources
| Ground-Based Flight Analogs
|
Controlled Research Analog, Short Duration (2 months or less) – isolated and confined with spaceflight mission scenario [e.g., HERA, NEEMO]
|
| Number of Subjects
|
32
|
Category:
Technology or Tool
Subcategory:
Informatics
Description:
Standardized data across the BMed, Team, and Sleep risks for HERA to be deposited into the LSDA and shared with other HERA investigators.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Roma, Pete
Short Title:
HFBP Exploration Measures in NEK
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
|
Procurement Mechanism(s):
|
|
Aims:
This will allow HRP to establish, evaluate, and manage a common set of measures for use in spaceflight and analog research to: develop baselines, systematically characterize risk likelihood and consequences, and assess effectiveness of countermeasures that work for human factors and behavioral performance risk factors. This task will provide “standard measures” as the foundation to achieve consistent research measures for data-sharing in HERA and to meet the highly constrained, operationally-focused data gathering and analysis that allows for greater consistency in the research methods that are very specific to NASA HRP standard measures development. Additionally, the set of BHP standardized measures in the NEK analog reflects the more operational nature of the measures while allowing the multiple and frequent internal and external collaborations required to execute this study.
Aims:
1. Provide a set of BHP standard measurements for investigators to use in proposed projects.
2. Enable comparison of multiple missions across spaceflight analog campaigns to quantify risk using reliable metric-based data.
3. Provide database for data-mining and integrative modeling and increase research data quality and transfer to LSDA.
This task will contribute to gap closure by facilitating all tasks using the IBMP NEK Chamber analog in the BMed, Sleep, and Team risk areas.
Ground Analog Resources
| Ground-Based Flight Analogs
|
Controlled Research Analog, Long Duration (4 months or more) – isolated and confined with spaceflight mission scenario [e.g., NEK/Russian Chamber], Controlled Research Analog, Medium Duration (2 to 4 months) – isolated and confined with spaceflight mission scenario, Controlled Research Analog, Short Duration (2 months or less) – isolated and confined with spaceflight mission scenario [e.g., HERA, NEEMO]
|
| Number of Subjects
|
18
|
Category:
Technology or Tool
Subcategory:
Informatics
Description:
Standardized data across the BMed, Team, and Sleep risks for IBMP NEK Chamber analog to be deposited into the LSDA and shared with other NEK analog Investigators.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Basner, Mathias
Short Title:
Hybrid Training - VR Exercise
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
|
Procurement Mechanism(s):
|
|
Aims:
The proposed study concentrates on assessing the effectiveness of regular physical exercise combined with an interactive virtual environment (VR), i.e. Hybrid Training to augment neurostructural, cognitive, physiologic, and social effects of prolonged confinement and isolation on subjects over-wintering in the space analog environment of the Antarctic Neumayer station (or an alternative analog facility). We also propose to compare these data to previous crews overwintering in Neumayer station without any countermeasure. Briefly, the research encompasses the following specific aims:
Aim 1: Investigate the effect of Hybrid Training on brain structure and function
Aim 2: Investigate the effect of Hybrid Training on cognitive performance
Aim 3a: Investigate the effect of Hybrid Training on biochemical markers of stress and neuroplasticity
Aim 3b: Investigate the effects of Hybrid Training on mood, depression, and subjective assessments of workload, stress, sleep quality, tiredness, sickness, and conflicts.
Aim 3c: Investigate the effect of Hybrid Training on sleep duration and sleep-wake rhythms using continuously wrist-worn actigraphy
Aim 3d: Investigate the effect of Hybrid Training on heart rate, heart rate variability, and sleep structure using monthly 24-h ECG measurements
Aim 3e: Investigate the effect of Hybrid Training on crew cohesion and team structure
Ground Analog Resources
| Ground-Based Flight Analogs
|
ICE Field Analog, Long Duration (4 months or more) – isolated, confined and extreme; may not have spaceflight mission scenario [e.g., Antarctica]
|
| Number of Subjects
|
18
|
Category:
Countermeasure
Subcategory:
Protocol
Description:
Methods and tools to provide sensory stimulation for the promotion of astronaut cognitive and behavioral health during long duration missions.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Roma, Pete
Short Title:
ISS HRP Spaceflight Exploration Measures (HFBP) for Gateway
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
|
Procurement Mechanism(s):
|
|
Aims:
This will allow HRP to establish, evaluate, and manage a common set of measures for use in spaceflight and analog research to: develop baselines, systematically characterize risk likelihood and consequences, and assess effectiveness of countermeasures that work for human factors and behavioral performance risk factors. This task will provide “standard measures” as the foundation to achieve consistent research measures for data-sharing in ISS and to meet the highly constrained, operationally-focused data gathering and analysis that allows for greater consistency in the research methods that are very specific to NASA HRP standard measures development. Additionally, the set of standardized measures on the ISS reflects the more operational nature of the measures while allowing the multiple and frequent internal and external collaborations required to execute this study.
Aims:
1. Provide a set of standard measurements from HFBP towards the HRP standard measures for investigators to use in proposed projects.
2. Enable comparison of multiple missions across spaceflight analog campaigns to quantify risk using reliable metric-based data.
3. Provide database for data-mining and integrative modeling and increase research data quality and transfer to LSDA.
This task will contribute to gap closure by facilitating all tasks using ISS in the BMed, Sleep, and Team risk areas and by testing measures and monitoring tools for the Deep Space Gateway missions.
Category:
Technology or Tool
Subcategory:
Informatics
Description:
Standardized data across the BMed, Team, and Sleep risks for ISS to be deposited into the LSDA and shared with other ISS Investigators, including use for future data-mining.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Hattar, Samer
Short Title:
Lighting CM for Behavioral Health and Cognition
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
|
Procurement Mechanism(s):
|
|
Aims:
This task will provide the state of the knowledge of using lighting as a countermeasure for cognitive and behavioral health issues affecting mood, affect, and wellbeing for long duration exploration missions. The work would include a literature review and conduct a series of up to 10 operational assessment interviews with relevant subject matter experts (SMEs) in related fields and analogous environments. The final deliverables would be a final report with findings and recommendations for the direction and nature of future research as well as a final presentation summarizing the project, findings and discussion with NASA participants.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
The final deliverables would be a final report with findings and recommendations for the direction and nature of future research as well as a final presentation summarizing the project, findings and discussion with NASA participants.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Brainard, George
Short Title:
Lighting Effects
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
|
Procurement Mechanism(s):
|
|
Aims:
Currently, the fluorescent-based “General Luminaire Assemblies” (GLAs) on the International Space Station (ISS) are reportedly dim and burning out. Crewmembers have complained about the lack of intensity in these lights, and their dim and static nature may be associated with circadian misalignment and sleep loss experienced on orbit.
As a result of a multi-disciplinary effort based out of the Johnson Space Center, in 2010 the ISS Program agreed to fund a new LED-based lighting system, called the Solid State Light Assemblies (SSLAs), for the ISS vehicle. This system will enable crewmembers to quickly adjust brightness and wavelength of the lights so lighting can support crew vision and provide a crew health countermeasure for circadian entrainment, sleep shifting, enhancing alertness and performance. Specifically, crewmembers will be able to toggle between a high intensity light enriched in the “blue” portion of the spectrum for the morning, night time operations and schedule shifting (“Phase Shift”); a crisp daytime light to support visual acuity (“General Vision”); and a low intensity, non-blue enriched light in the evening (“Pre Sleep”).
The requirements for this lighting system were based on the best available scientific evidence, as well as technical constraints of the ISS vehicle (e.g., no wireless configuration)
The purpose of this task is to evaluate on the ISS whether the proposed lighting protocols using the SSLAs on orbit lead to their intent of maintaining circadian alignment and promoting sleep at night and performance during the day, and, as needed, during night time operations. A preliminary ground analog study in a high-fidelity laboratory analog will precede the flight portion of this investigation.
Findings will be relevant for the Space Human Factors and Habitability (SHFH) Element vehicle and habitat development, and will inform medical protocols for using light as a non-pharmaceutical countermeasure for circadian desynchronization on orbit.
Other Resources
| Other Resources Needed?
|
Yes
|
Category:
Countermeasure
Subcategory:
Protocol
Description:
Findings will inform medical requirement for using light as an inflight countermeasure for exploration missions. Findings will also inform habitat requirements for future missions and NASA - STD - 3001 Volumes 1 and 2.
Internal Customers:
None
External Customers:
SMOD - Space Medicine Operations Division
Is a Customer-Supplier Agreement (CSA) Required?
Yes
Task Book:
Entry Unavailable
Principal Investigator:
Roma, Peter
Short Title:
SHAQ Development and Validation
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
|
Procurement Mechanism(s):
|
|
Aims:
This task is in response to an urgent need to develop and validate a Space Flight Habitability and Acceptability Questionnaire (SHAQ) to assess the behavioral health and performance impacts of volume, layout, and other design features of vehicles and habitats for long-duration exploration spaceflight and other operational environments.
Aim 1: Conduct a review to identify primary constructs and themes relevant to habitability effects on individual and team behavioral health and performance in operational environments.
Aim 2: Develop candidate questionnaire items based on the constructs and themes identified in the literature review and validated against coded videos from the ISS Habitability Study (PI: Greene) and in consultation with Subject Matter Experts.
Aim 3: Empirically assess the initial sensitivity, construct validity, divergent validity, and concurrent validity of SHAQ in HERA C5.
Aim 4: Refine SHAQ based on the results of the HERA validation study.
Aim 5: Draft a NASA Technical Report and/or manuscript for publication that (a) provides the results of SHAQ research and development efforts and (b) offers habitability recommendations for future deep space exploration missions.
Aim 6: Author a SHAQ User Guide for public dissemination providing details on administration, scoring, and data management and interpretation.
Ground Analog Resources
| Ground-Based Flight Analogs
|
Controlled Research Analog, Short Duration (2 months or less) – isolated and confined with spaceflight mission scenario [e.g., HERA, NEEMO]
|
| Number of Subjects
|
16
|
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
This task will provide evidence regarding changes in behavioral health and performance, relative to changes in habitable volume, layout, and design, in isolation and confinement. A final report will summarize findings from our experimental protocol in HERA.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Standard
Subcategory:
Update
Description:
This task may result in information that could inform a standard in the NASA Habitability Standards 3001 Vol. 2. As an example, standards relative to private crew quarters may be informed in part by the results of this investigation. If applicable, we will update relevant standards.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Technology or Tool
Subcategory:
Informatics
Description:
We will deliver the HERA validated Spaceflight Habitability Acceptability Questionnaire (SHAQ) along with an accompanying manual (outlining the psychometric properties of the measure along with considerations for format for delivery).
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Rose, Raphael
Short Title:
SMART-OP MOD
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
|
Procurement Mechanism(s):
|
|
Aims:
Aim 1: To evaluate the effectiveness, usefulness, and usability of SMART-OP with a sample of flight controllers at Johnson Space Center in a randomized controlled trial (RCT) by comparing SMART-OP to an attention control group (AC). This population will evaluate the program’s use with an analogous sample to astronauts.
Aim 2: Provide feedback to SFRM and MOD based on data from the RCT and suggest modifications and implementation strategies of SMART-OP for use with astronauts.
Exploratory Analyses: To examine responses to an acute stressor (Mental Arithmetic Task and Mirror Tracing task), saliva samples will be collected and assessed for biomarkers of stress (cortisol and α amylase) as well as neuropsychological performance. To examine chronic stress responses, we will analyze 24-hour heart rate and urinary cortisol data. Main statistical analyses will be repeated measure ANOVAs (Time x Condition).
Other Resources
| Other Resources Needed?
|
Yes
|
Category:
Countermeasure
Subcategory:
Prototype Hardware or Software
Description:
Software validated with individuals analogous to astronauts.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
MOD - Mission Operations Directorate
Is a Customer-Supplier Agreement (CSA) Required?
Yes
Task Book:
Entry
Principal Investigator:
Basner, Mathias
Short Title:
Spatial Cognition
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
|
Procurement Mechanism(s):
|
|
Aims:
This study is part of the 1-Year Mission Complement of studies led by the NASA Human Research Program. This study represents an international collaboration consisting of two projects: Project A: Neurostructural and Cognitive Changes During Long Duration Low-Earth Orbit Missions: Cognition (PI Basner) and Project B: Spatial Cognition and Hippocampal Plasticity During Long-Duration Low-Earth Orbit Missions: HypoCampus in i1YMP (PI Stahn)) with synergistic aims to be carried out in a joint effort by DLR/ESA and NASA. It addresses the HRP Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders, HRP's requirement to demonstrate the presence or absence of unacceptable deleterious neurocognitive effects beyond six-month expeditions. Two in scanner techniques, fMRI while performing the Cognition test battery (Part A) and a special grid cell scan and Pattern Separation Task (Part B), they will determine the biological basis for any changes in cognitive performance, with a focus on hippocampal plasticity (Part B). The specific aims of this study are:
Project A:
-
Effects of Long-Duration Low-Earth Orbit Missions on Cognition Performance
-
Normative Cognitive Performance Data as a Baseline for Future Long-Duration Missions
-
Brain Structural, Functional and Connectivity Substrates of Changes in Cognitive Performance Induced by Long-Duration Low-Earth Orbit Missions
Project B:
-
Visuospatial Brain Domain Changes Induced by Low-Earth Orbit Missions
-
Effects of Long-Duration Low-Earth Orbit Missions on Visuo-Spatial Cognition
-
Biological Basis of Neurocognitive Changes During Low-Earth Orbit Missions
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Determine if cognitive performance assessed during months 7-12 in the year-long crew compares to cognitive performance assessed during months 1-6 in the standard 6 month crew adjusting for any difference in performance between crews pre-flight. Assess the presence or absence of deleterious neurocognitive effects beyond the experience base of six-month expedition.Assess spatial cognition before, during and after spaceflight, determine key neurotrophic and growth factors at identical time points and identify specific changes in hippocampal plasticity and visuospatial performance in order to predict changes in neuroplasticity and neurobehavioral coping during spaceflight.Demonstrate the impacts of isolation and environmental stressors on visuospatial brain domain changes and spatial navigation.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Technology or Tool
Subcategory:
Informatics
Description:
Generate and deliver to NASA a normative database and a database that can serve as a baseline for future long duration missions and one for standard duration missions (should analyses indicate that inflight performance during months 7-12 differs from performance during months 1-6).This study will deliver a single comprehensive set of integrated neuroimaging and neurocognitive tools for the evaluation and ultimately prevention of adverse effects on brain structure and function.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Stankovic, Aleksandra
Short Title:
VR Stimulation in ICE
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Active - Currently funded and in progress
|
Procurement Mechanism(s):
|
|
Aims:
This study will investigate the feasibility of nature based sensory stimulation using VR to promote stress management and relaxation by (1) adding an interactive component to the VR-based sensory stimulation, to promote engagement and to facilitate therapeutic release; (2) deploying and testing this platform in ICE for feasibility and validation; (3) incorporating non-intrusive physiological monitoring, and (4) examining quantifiable neurophysiological response to stimulation exposure, individual variability in responses, and longitudinal and dose-response characteristics of exposure impacts.
Aim 1: To evaluate the acceptance, perceived effectiveness, and operational feasibility of various VR parameters for relaxation, restoration, and therapeutic release, based on usage in operational ICE.
Aim 2: To manipulate various aspects of VR presentation (e.g. duration, scene content, biofeedback presentation, addition of haptic cues) in the laboratory to optimize the VR experience for relaxation, restoration, and therapeutic release.
Aim 3: To assess experimentally the impact of various core aspects of a VR based sensory stimulation platform for relaxation and therapeutic release (e.g. length, scene content, interactivity, haptic cues) by altering these elements and assessing before and after VR presentation (1) psychophysiological response (to assess relaxation) and (2) performance on an operationally-relevant task (as a measure of cognitive performance and attention restoration), within ICE across the mission duration.
Ground Analog Resources
| Ground-Based Flight Analogs
|
Controlled Research Analog, Short Duration (2 months or less) – isolated and confined with spaceflight mission scenario [e.g., HERA, NEEMO], ICE Field Analog, Long Duration (4 months or more) – isolated, confined and extreme; may not have spaceflight mission scenario [e.g., Antarctica]
|
| Number of Subjects
|
0
|
Category:
Countermeasure
Subcategory:
Protocol
Description:
An operational protocol for understanding the psychophysiological processes related to sensory stimulation, crew health, and human performance. These processes may help identify individual differences related to environmental stressors and the need for sensory stimulation and approaches that can lead to new insights into how sensory stimulation affects physiological and psychological functioning (e.g., neurobiological reactivity, sensorimotor performance).
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Completed
Task Book:
Entry
Principal Investigator:
Wu, Peggy
Short Title:
ANSIBLE VR Support/Adaptation CM
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
Develop a countermeasure that utilizes virtual reality for support/adaptation of the crew during a long duration mission.
ANSIBLE – A Network of Social Interactions for Bilateral Life Enhancement, is a communication and social support toolset which enables multi-faceted human-human and human-virtual agent interactions designed to accommodate technical and environmental limitations of long duration space flight.
This is an SBIR Phase 2 project.
An SBIR Phase 2 Enhancement (2E) was awarded to the SBIR firm, SMART Information Flow Technologies (SIFT), to extend the ANSIBLE virtual reality platform into the realm of telehealth as a communication tool that promotes a therapeutic alliance between therapists and their clients. The SIFT PI changed from Peggy Wu to Jeremy Gottlieb.
Ground Analog Resources
| Ground-Based Flight Analogs
|
Controlled Research Analog, Long Duration (4 months or more) – isolated and confined with spaceflight mission scenario [e.g., NEK/Russian Chamber], Controlled Research Analog, Short Duration (2 months or less) – isolated and confined with spaceflight mission scenario [e.g., HERA, NEEMO]
|
| Number of Subjects
|
28
|
Category:
Countermeasure
Subcategory:
Prototype Hardware or Software
Description:
Prototype software system for supporting teams on exploration missions. Phase I anticipated in 2013, Phase II in 2014-2015. Additional time allowed for further refinement/development/enhancement as technology is matured in preparation for transition to operations, or in preparation for use in future missions.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Raber, Jacob
Short Title:
apoE
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
1A. Determine if E isoform is associated with radiation-induced apoptosis of neural precursor cells in the dentate SGZ
1B. Determine the role of E isoform in the development of radiation-induced cognitive deficits and whether the severity of these deficits are associated with apoptosis of neural precursor cells in the dentate SGZ. Mice will be tested 3 months following radiation
1C. Determine how E isoform affects neurogenesis following 56Fe- irradiation, and determine if this effect is related to the severity of radiation-induced cognitive deficits
2A. Determine if the presence of a specific E isoform is associated with markers of oxidative stress following radiation injury
2B. Determine if the antioxidant a-lipoic acid enhances cognitive function and reduces radiation-induced cognitive impairments and whether this ability is E isoform-dependent.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research will provide evidence on impact of individual sensitivity and antioxidants on acute cognitive decrements following SR exposure, in support of closure of CNS Gap 3.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Buckey, Jay
Short Title:
Autonomous Behavioral Health Countermeasures - VSS
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The aims of the proposed project are to:
Aim #1: Customize the Virtual Space Station program for use by astronauts by evaluating the program in an isolated environment (i.e., Antarctica) and collecting detailed information on program use, including user choices, ease of navigation, usability and acceptability.
Aim #2: Modify the existing VSS program to add enhanced conflict resolution content and an integrated behavioral health assessment.
Aim #3: Enhance the VSS program to include a mood enhancement system that allows users to experience immersive relaxing situations using virtual reality.
Ground Analog Resources
| Ground-Based Flight Analogs
|
Controlled Research Analog, Long Duration (4 months or more) – isolated and confined with spaceflight mission scenario [e.g., NEK/Russian Chamber], ICE Field Analog, Long Duration (4 months or more) – isolated, confined and extreme; may not have spaceflight mission scenario [e.g., Antarctica]
|
| Number of Subjects
|
36
|
Category:
Countermeasure
Subcategory:
Protocol
Description:
Countermeasures for stress management.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Desai, Rajeev
Short Title:
CBS NHP CNS Radiation/Performance Data Mining (Desai)
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
- Conducting a comprehensive and systematic evaluation of existing research in NHP on the acute and long-term impact of exposure to spaceflight stressors on NHP CNS-related function;
- Identifying applied and mechanistic research gaps on the acute and long-term impact of exposure to spaceflight stressors on CNS-related function that need to be conducted in a translationally-relevant manner in NHP
- Providing recommendations for NASA regarding the availability, validity, and limitations of NHP models in future targeted research that will address critical gaps to mitigate these spaceflight hazards that currently have the potential to catastrophically “surprise” NASA by an event or response to circumstances (spaceflight stressors) during deep space missions they did not anticipate.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
1. A comprehensive and systematic evaluation of existing research on the acute and long-term impact of exposure to spaceflight stressors on NHP CNS-related neurobiological, neurochemical, neurobehavioral and cognitive function.
2. Describe critical research gaps and priorities in NHPs related to the CBS Integration Research Plan that ought to be considered by NASA moving forward to bridge the key knowledge gaps that currently exist in deciphering rodent data to humans. Provide a consideration of NHP model as gold standard animal model for assessing the dose-effects of radiation on operationally-relevant Brain Performance Pathways, POL/PEL development, and potential pharmaceutical development as countermeasures.
3. Provide a roadmap of recommendations for NASA regarding the availability, validity, and strengths and limitations of NHP models in future targeted research, including points of contact between existing NASA-relevant rodent assays and functional NHP analogs.
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Hienz, Robert
Short Title:
CMs for Neurobehavioral Vulnerabilities to Space Radiation
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
Aim 1: Assess the degree to which likely biomedical countermeasures can mitigate the known effects of space radiation on cognitive neurobehavioral functions relevant to astronaut mission performance.
Aim 2: Assess the mechanisms of action of effective radioprotective countermeasures on the CNS.
Category:
Study Results
Subcategory:
Customer Requested Study or Analysis
Description:
Final Report Summarizing Study Results.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Graber, Mark
Short Title:
Cognitive Bias and Decision Making Training RR
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The task consists of an evidence review of the published literature on the topics of cognitive biases, logical fallacies, and the reduction of cognitive dissonance with a focus on work in high-stakes environments such as medical care, military operations, and aircraft operations; and in the evidence for interventions such as training and education to reduce the errors caused by these factors. Additionally the task includes operational assessment interviews with up to ten subject matter experts at NASA or relevant analog environments to determine the state of practice and need within the NASA environment.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Final Report will summarize the peer-reviewed evidence and interviews with subject matter experts on cognitive biases, logical fallacies, and the reduction of cognitive dissonance affecting thinking and decision making.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Haley, Gwendolen
Short Title:
Effects of Alpha Lipotic Acid on Mice
Responsible HRP Element:
Space Radiation
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
- To determine the short-term effects of 56Fe radiation irradiation on hippocampal function and assess whether these effects are sex-dependent. Mice will be irradiated at 0, 0.1, 0.2, or 0.5 Gy and behaviorally tested 1-2 weeks following radiation.
- To determine whether the severity of the cognitive effects are associated with reduced choline acetyltransferase (ChAT) immunoreactive cell bodies in the medial septum and nucleus basalis and ChAT immunoreactive fibers in the hippocampus and cortex. Following behavioral testing, ChAT cell number and fiber density will be determined using immunohistochemistry and measures of ROS by western blot.
- To determine the ability of the dietary supplement lipoic acid (LA) to antagonize the effects of 56Fe irradiation on hippocampus-dependent cognitive function, measures of ROS, and ChAT immunoreactive cell bodies in the medial septum and nucleus basalis and ChAT immunoreactive fibers in the hippocampus and cortex. Mice will be sham-irradiated or irradiated at a dose causing maximal cognitive injury in Aim 1 and receive regular diet or LA-containing diet starting one week prior to behavioral testing. Brains will be processed as in Aim 2.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Final Report
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Feltz, Deborah
Short Title:
Exercise Compliance and Motivation
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| Human Health Countermeasures (HHC) Element |
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The specific aims of the project are to:
(1) Develop software to create software-generated (SG) exercise partners and interface with exercise equipment similar to what is available on the International Space Station (i.e., cycle ergometer) (CRL-4). An aerobic stationary cycle exergame that integrates the SG exercise partner will also be developed as part of in this effort. SG partner features will be tested with an astronaut focus group.
(2) Test various design features of the SG partner within designed exercise games to determine the most effective features for enhancing motivation to exercise, enjoyment, confidence, and connectedness (CRL-5). Test subjects will be analogous to current astronauts in terms of fitness levels.
(3) Test whether exercising with an SG partner over 24-week time period, compared to exercising alone, leads to better aerobic capacity and muscle strength, adherence to the exercise regimen, and enhanced enjoyment in the activity, self-efficacy, and sense of social connectedness (CRL-6). Test subjects will be analogous to current astronauts in terms of fitness levels.
This NSBRI NRA is a collaborative study with implications for both BHP and HHC. It is collaborative in that it relates physical exercise for maintaining musculoskeletal health in spaceflight to the exercise experience and how to motivate individuals to be compliant with exercise regimens.
This task also informs the Sensorimotr discipline area: SM 28
Other Resources
| Other Resources Needed?
|
Yes
|
Category:
Technology or Tool
Subcategory:
Computational Models or Simulations
Description:
Software that will create software-generated (SG) exercise partners and interface with exercise equipment that is similar to what is available on the International Space Station (i.e., cycle ergometer).
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Bryan, Craig
Short Title:
Expectations Training RR
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
This task will be a research study to develop and test the feasibility, acceptability, and effectiveness of a training astronauts in the expectations of the unique stressors of long duration spaceflight on astronaut cognitive and behavioral health.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Practice Guidelines, Training Guidelines for expectations training for long duration exploration missions
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Billman, Dorrit
Short Title:
Generalizable Skills
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
Long-duration, exploration-class missions (LDEM) present new training challenges, as these missions significantly differ from our past exploration experience. We cannot predict all the tasks crewmembers may be required to perform during such missions, and thus cannot design pre-flight training to address tasks about which we do not yet know. This lack of knowledge requires a shift from task-based training typical of past and current space missions to skill-based training that focuses on the long-term retention and generalization of pre-flight training to transfer to new and unexpected onboard operations. However, we do not know the characteristics of skills and knowledge that lead to better retention, generalization, and transfer nor do we know the best training principles that support retention, generalization, and transfer.
-
Identify characteristics of skills and knowledge that lead to better retention, generalization, and transfer. (i.e. identify what enables learners to apply trained skills and knowledge to new tasks.)
-
Identify training practices that support retention, generalization, and transfer, such as integrated training in the operational context.
These results will help close the gap on generalizable skills by identifying characteristics of skills and training practices that support training retention, generalization, and transfer.
Other Resources
| Other Resources Needed?
|
Yes
|
Category:
Study Results
Subcategory:
Customer Requested Study or Analysis
Description:
The deliverable for Generalizable Skills is a final report that will identify characteristics of skills and knowledge that lead to better retention, generalization, and transfer, (i.e. the report will identify what enables learners to apply trained skills and knowledge to new tasks), and identify training practices that support retention, generalization, and transfer, such as integrated training in the operational context.
This report will help close the gap on generalizable skills by identifying characteristics of skills and training practices that support training retention, generalization, and transfer.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Rabin, Bernard
Short Title:
Heavy NeuroB
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
- To further characterize HZE particle-induced behavioral and neurochemical deficits
- To determine the neural mechanisms underlying the changes in performance
- To determine how individual characteristics (age and gender) may influence the responsiveness to HZE particle irradiation
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research will provide evidence on LET dependence of behavioral and neurocognitive endpoints following radiation exposure in support of CNS Gap 1 closure.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
O'Banion, Kerry
Short Title:
HZE Neuroinflammation
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
- In our first aim we will endeavor to use a sufficient dose range in order to compare outcomes with the physiologic and pathologic endpoints established in our current data using gamma radiation.
- In our second aim, we will use specific inhibitors of cyclooxygenase-2 to determine if prostaglandins play a key role in the neuroinflammatory response to HZE particles.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research to test efficacy of a biological countermeasure on mitigation of neuroinflammation associated with long term cognitive impairment following radiation exposure, in support of CNS Gap 4 closure.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Greene, Maya
Short Title:
ISS Habitability (NHV/HAB Assessment)
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
Methods and tools (i.e., iSHORT, iQ&A) were developed and used to collect near real-time human factors and habitability data during spaceflight missions. Having a means to collect near real-time data reduces reliance on human memory and has the ability to capture small issues that may have a cumulative effect. These issues may result in crew frustration and inefficiencies. This study had two aims.
Aim 1: Using near-time reporting, characterize human factors and habitability aboard the ISS, which includes self-reported negative, neutral, and positive observations and assessments.
Aim 2: Preliminarily characterize crew utilization and perceptions of specific ISS habitat components/locations.
These efforts resulted in recommendations for future vehicle design, as well as proposed changes to NASA standards.
Ground Analog Resources
| Ground-Based Flight Analogs
|
Controlled Research Analog, Short Duration (2 months or less) – isolated and confined with spaceflight mission scenario [e.g., HERA, NEEMO]
|
| Number of Subjects
|
10
|
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
The deliverable for this task was a report: ISS Habitability Assessment. This report describes the research performed under the Habitability Assessment of International Space Station (ISS Habitability) Human Factors and Behavioral Performance (HFBP) Directed Research Project. This study addressed the Risk of an Incompatible Vehicle/Habitat Design by collecting and analyzing data about human factors and habitability on board the ISS and making recommendations for future vehicle and mission designers. The study utilized two custom iPad applications, Space Habitability Observation Reporting Tool (iSHORT) and iQuestion and Answer (iQ&A), which allowed participants to make open-ended observations about their living and working environment and respond to questionnaires. Six ISS crewmembers participated in the study, one 1-year crewmember and five standard-duration crewmembers. Data was collected throughout the participants’ missions. Participants were asked to capture observations about their environment about once every two weeks; to capture a walk-through video of an area of ISS about once per month; to narrate a task about once per month; to complete a human factors and habitability questionnaire three times per mission; and to participate in a principle investigator (PI) conference with the investigator team following each questionnaire. Content analysis was used to categorize the data and draw general conclusions in order to make recommendations for future vehicle and habitat design.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
ISS Flight Crew Integration
Is a Customer-Supplier Agreement (CSA) Required?
Yes
Task Book:
Entry
Principal Investigator:
Klerman, Elizabeth
Short Title:
Light Pulse CM
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
SA1) test the hypotheses that deployment of the Dynamic Lighting Schedule using high color temperature intermittent light; (1) will significantly increase the rate of circadian adaptation per minute of light exposure, as measured using Dim Light Melatonin Onset before and after the shift, and (2) will significantly improve cognitive performance, subjective alertness and objective EEG correlates of alertness (suppression of EEG-derived delta-theta activity [0.5-5.5 Hz]) and enhancement of EEG-derived high-alpha activity [10.5-12 Hz]) per minute of light exposure as compared to continuous light during the most efficient schedule (gradual or acute shift of the sleep-wake cycle) determined by a separately funded NSBRI research grant.
SA2) amend their mathematical model of the effects of light on the human circadian pacemaker and the linked model of the effects of length of time awake and circadian phase on performance and alertness to include results using the new ISS lighting: circadian phase-shifting, wavelength-specific, and direct alerting effects.
Category:
Countermeasure
Subcategory:
Protocol
Description:
Validated and more efficient prescriptions for lighting on ISS and exploration.
Internal Customers:
None
External Customers:
Med Ops - Medical Operations
Is a Customer-Supplier Agreement (CSA) Required?
Yes
Task Book:
Entry Unavailable
Principal Investigator:
Langer, Ellen
Short Title:
Mindfulness, Recreation, & Relaxation RR
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The task consists of an evidence review of the published literature on mindfulness, other relaxative techniques, and recreational activities and their role in promoting mental health and the prevention of cognitive or behavioral symptomology in populations in high-stress environments with an emphasis on populations and environments that are analogous to spaceflight. Additionally the task includes operational assessment interviews with up to ten subject matter experts at NASA or relevant analog environments to determine the state of practice in this area and need for additional work within the NASA environment.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
final report with findings and recommendations for the direction and nature of work needed to promote mental health and the prevention of cognitive or behavioral symptomology in populations in high-stress environments as well as a final presentation summarizing the project, findings and discussion with NASA participants.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Nelson, Gregory
Short Title:
Oxidative Stress
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The project will characterize behavioral, electrophysiological, biochemical and structural changes both in vivo and in vitro. Radiation-elicited oxidative stress mechanisms will be investigated as important mediators of the biological responses in both wild type and mutant animals. In addition to characterization of normal tissue responses, the potential enhancement of three late risks by radiation exposure will be explored. These are seizures, ischemic injury and traumatic injury. Mathematical models of the neurotoxicity responses will developed for use in estimating risks and fitted to project-specific data and previously-published observations.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Evidence on the roles of reactive oxygen species and neurogenesis in mediating the effects of radiation exposure on acute and late CNS function. Evidence will contribute to CNS gap 1 closure by providing mechanistic insight into acute/early radiation effects on the CNS.
Internal Customers:
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Evidence on the roles of reactive oxygen species and neurogenesis in mediating the effects of radiation exposure on acute and late CNS function. Evidence will contribute to CNS gap 1 closure by providing mechanistic insight into acute/early radiation effects on the CNS.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Evidence on the roles of reactive oxygen species and neurogenesis in mediating the effects of radiation exposure on acute and late CNS function. Evidence will contribute to CNS gap 1 closure by providing mechanistic insight into acute/early radiation effects on the CNS.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Limoli, Charles
Short Title:
Oxidative Stress CNS
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
Our proposal is focused on analyzing the effects of space radiation on these critical populations of multipotent neural stem and precursor cells. We have developed the technology to isolate and grow these cells in culture and will use a variety of techniques to analyze how cells exposed to space radiation change. We will monitor the time course of oxidative stress in these cells and how that depends on the dose, the dose rate and type of radiation applied. We will determine how radiation-induced oxidative stress impacts cellular proliferation, signaling between cells, cell fate and survival.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Characterization of the role of radiation induced oxidative stress in acute CNS responses to space radiation exposure. This data will provide mechanistic insights in support of CNS gap 1 closure.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Limoli, Charles
Short Title:
Stem Cell Plasticity
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
- One aspect this proposal will focus on is how radiation leads to the types of changes in the brain that might lead to impaired cognition. Much of our past work has demonstrated that the sensitive populations of neural stem and precursors cells that are important to cognitive health exhibit long-lasting chemical changes caused by prior radiation exposure. These changes have been linked to many of the adverse effects found in the brain after irradiation, and our present study will continue to identify the pathways that are activated by irradiation that cause these long-term and adverse chemical changes.
- Another aspect of our proposal relates to the rate at which cells are exposed to the radiation. A given dose of total radiation can be given over short or long time frames; if that exposure time is short then the rate is higher that if that dose is delivered over longer periods of time. Much of our past data of space radiation effects in the brain have been done under conditions of high dose rate, largely due to a number of practical limitations. In space however, most dose rates are low, and because the response of cells might differ, studies are needed to determine how cells respond to the types of radiation in space when delivered at low dose rates. Our current proposal will compare the types of changes found in neural precursor cells at low dose rate to those changes found previously at high dose rate. Results from these studies will be critical in enhancing our knowledge base of the risks associated with exposure of the brain to the radiation fields in space.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research will investigate dose-rate effects on radiation-induced oxidative stress response in neural precursor cells, providing evidence in support of CNS Gap 2 closure.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
O'Banion, Kerry
Short Title:
Systemic Inflammation
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
we will explore the effects of protons and mixed particle radiation, at doses and fluences expected during space travel, in the brain and lung as well as the systemic circulation of mice. Dose and time dependent alteration in inflammatory indices will be correlated with brain and lung degenerative changes, including failure of hippocampal neurogenesis and alterations in hippocampal dependent learning. We will also explore whether space radiation influences Alzheimer's disease pathogenesis using a unique transgenic mouse model and lung inflammation following challenge with inhaled lipopolysaccharide.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual Report
Internal Customers:
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual Report
Internal Customers:
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual Report
Internal Customers:
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Final Report
Internal Customers:
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Chabal, Sarah
Short Title:
Team Resilience
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The purpose of this task is to investigate the factors that make teams resilient over long durations in high stress environments along with interventions to enable NASA to compose highly resilient crews for long duration exploration missions. This is a Collaborative effort with the Navy. Addresses metric for interim progress (1.) identify the set of measures, key indicators, and key mission attributes that can be used for the algorithm to inform decisions on crew composition for autonomous exploration missions and (2.) develop validation criteria relating psychological and behavioral measures to team function and mission scenarios and attributes.
Ground Analog Resources
| Ground-Based Flight Analogs
|
Controlled Research Analog, Short Duration (2 months or less) – isolated and confined with spaceflight mission scenario [e.g., HERA, NEEMO]
|
| Number of Subjects
|
16
|
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Final report providing evidence on the effects of resilience on performance and team composition on resilience. Promotes gap closure by addressing metric for interim progress (1.) identify the set of measures, key indicators, and key mission attributes that can be used for the algorithm to inform decisions on crew composition for autonomous exploration missions.
CB is also a customer, in addition to Mission Operations and Med Ops.
Internal Customers:
None
External Customers:
MOD - Mission Operations Directorate
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Final report providing evidence on the effects of resilience on performance and team composition on resilience. Promotes gap closure by addressing metric for interim progress (1.) identify the set of measures, key indicators, and key mission attributes that can be used for the algorithm to inform decisions on crew composition for autonomous exploration missions.
CB is also a customer, in addition to Mission Operations and Med Ops.
Internal Customers:
None
External Customers:
Med Ops - Medical Operations
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Countermeasure
Subcategory:
Protocol
Description:
Protocol for improving composition of teams to increase team resilience for long duration exploration missions. Promotes gap closure by addressing metric for interim progress (2.) develop validation criteria relating psychological and behavioral measures to team function and mission scenarios and attributes.
CB is also a customer, in addition to Mission Operations and Med Ops.
Internal Customers:
None
External Customers:
MOD - Mission Operations Directorate
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Countermeasure
Subcategory:
Protocol
Description:
Protocol for improving composition of teams to increase team resilience for long duration exploration missions. Promotes gap closure by addressing metric for interim progress (2.) develop validation criteria relating psychological and behavioral measures to team function and mission scenarios and attributes.
CB is also a customer, in addition to Mission Operations and Med Ops.
Internal Customers:
None
External Customers:
Med Ops - Medical Operations
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Rabin, Bernard
Short Title:
NeuroB
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The objectives of the experiments detailed in this proposal are to describe and evaluate the effects of exposure to protons on CNS function and behavior and to characterize the role of individual differences, such as gender and age, in modulating the effects of exposure on neurocognitive endpoints.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research will provide evidence on impact of age, sex and LET on biochemical and behavioral alterations following radiation exposure, in support of CNS Gap 3 closure.
Internal Customers:
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Keeton, Kathryn
Short Title:
Autonomous Operational Teams
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
Review literature on autonomy and team performance.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Report on autonomy and team performance
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Cartreine, James
Short Title:
Self Help Conflict Management
Responsible HRP Element:
Behavioral Health and Performance
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
1. Create a countermeasure tool that will be used to help crewmembers when interpersonal conflict arises.
2. Test countermeasure in ground studies (possibly through randomized clinical trials)
3. Create final report that provides analysis and conclusion of countermeasure performance and provides future recommendations for its use.
Category:
Countermeasure
Subcategory:
Prototype Hardware or Software
Description:
Countermeasure software primarily for exploration missions, regarding conflict resolution.
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Davis, Catherine
Short Title:
Neurobehavioral SR
Responsible HRP Element:
Behavioral Health and Performance
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The present proposal addresses this need via the application of an animal model to determine:
- The long-term effects of radiation exposure on cognitive neurobehavioral function and the dopamine neurotransmitter system; and
- The effectiveness of flaxseed dietary supplementation to mitigate the neurobehavioral and neurochemical effects of radiation exposure.
- To determine DAergic and inflammatory protein levels in radiation-induced, neurobehaviorally impaired Fischer and Lewis rats and in radio-protectant-treated flaxseed rats.
- To assess functional changes in dopaminergic neurotransmission following head-only proton radiation using well-characterized dopamine receptor-mediated behaviors (i.e., DA agonist-induced yawning and hypothermia)
Other Resources
| Other Resources Needed?
|
Yes
|
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual and Final Reports summarizing study results
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Davis, Catherine
Short Title:
Neurobehavioral SR Follow-On
Responsible HRP Element:
Behavioral Health and Performance
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
Assess the effects of radiation on core body temperature and spontaneous locomotor activity rats trained to perform the rodent psychomotor vigilance test (rPVT).
Other Resources
| Other Resources Needed?
|
Yes
|
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Final report summarizing study results
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Johnston, Smith
Short Title:
Individualized Meds Protocols
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
1. Test the feasibility of a protocol to use with astronauts and other NASA personnel (e.g., flight surgeons, flight directors and flight controllers)
2. Assess potential carry over effects from sleep medications used during spaceflight operations (including overseas training periods), and following an abrupt awakening from sleep.
Category:
Countermeasure
Subcategory:
Protocol
Description:
report on pilot study
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Kearney, A.
Short Title:
Environmental Factors Review
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
This will be a Research Requirement to examine the variables of the physical environment (privacy, monotony, light-dark issues, and individualized control) that relate to behavioral health and performance. The outcome will inform habitability requirements and the BHP and SHFH research plans, as well as address items being considered by the Net Habitable Volume Community of Practice.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Report will describe evidence, operational assessment, and research and implementation recommendations related to environmental countermeasures.
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Flynn-Evans, Erin
Short Title:
Future Vehicle Environment RR
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The purpose of this task is to mine spaceflight data regarding habitability stressors and countermeasures, review existing literature, and conduct an operational assessment to inform future research needs and/or provide habitability-related recommendations for sleep in exploration.
This task will be conducted collaboratively with SHFH.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
This task will inform specific future research needs (if any) based on a thorough evidence review and an operational assessment. Results could help inform habitability-related countermeasure development for sleep in an exploration vehicle environment. The task contributes to gap closure by potentially yielding an additional mitigation strategy for future missions.
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Whitmire, Alexandra
Short Title:
NHV
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The objectives of the NHV CoOP include defining a research plan for addressing habitability and providing updates to standards and vehicle/habitat design requirements. Objectives for 2013 include a research plan for HRP.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Report describing the minimum habitable volume for long duration missions. SHFH to lead up the integrated research plan effort.
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Johnston, Smith
Short Title:
Sleep Meds Phase II
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
1) Characterize the effects of the most commonly used sleep medications and dosages on performance after an unplanned awakening
2) Provide the foundation for future development of individualized protocols for sleep medication use during training and on-orbit.
Other Resources
| Other Resources Needed?
|
Yes
|
Category:
Countermeasure
Subcategory:
Protocol
Description:
Report on findings from study. Protocol for individualized testing of sleep medications to be come medical requirement. Following this study, a decision point will assess whether future studies are needed. Delivery date reflects delivery of report from study PI.
Internal Customers:
None
External Customers:
Med Ops - Medical Operations
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Barger, Laura
Short Title:
Mars Lander CM
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
1. Provide personnel a 60-minute education session on sleep and sleep disorders, circadian rhythms and fatigue, including advice about sleep strategies and countermeasures that can be used to combat fatigue while on duty and increase sleep quality/quantity while off-duty, and countermeasures to facilitate circadian entrainment to the Mars sol. We will provide supportive educational materials (e.g., handouts, webbased resources) regarding those strategies and will seek to set up a website to support ongoing education throughout the mission.
2. Determine feasibility and acceptability of countermeasures used to facilitate circadian misalignment and to improve alertness via participants completing questionnaires.
3. Test hypothesis that there will be greater sleep disruption (less sleep duration as estimated by actigraphy) and greater dissatisfaction with sleep quality (subjective analysis via daily questionnaire) when scheduled to work on the Mars sol as compared to baseline data collected while working on a traditional earth (24 hr day) schedule.
4. Test the hypothesis that working on a Mars sol schedule will result in circadian misalignment (as assessed by analysis of melatonin secretion [6-sulfatoxymelatonin in urine]).
5. Test the hypothesis that decrements in performance (PVT and ANAM testing), increased on-the-job errors, and increased adverse safety outcomes (e.g., accidents and injuries) will be associated with sleep disruption and circadian misalignment.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Deliverable is a report that assesses the impact of ground crews of adapting to a Mars day.
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Vessel, Edward
Short Title:
Sensory Stimulation Augmentation Tools (RR)
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
This task will define the requirements for research related to the identification and development of methods and tools as a countermeasure for sensory deprivation experienced in an Isolated, Confined and Extreme (ICE) environment. These methods and tools are specifically targeted to augment sensory faculties (e.g., visual, tactile, olfactory, taste, and auditory sensations), and may include technologies related to plant production, virtual reality and exercise, etc.This is a research requirements (RR) task, consisting of a literature review and an operational assessment.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Report evaluating evidence on sensory simulation, and an operational assessment. May provide research and technology development recommendations.
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Locke, James
Short Title:
Sleep Quality Questionnaire SQQ
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
(1) Obtain and analyze subjective data from a representative sample of current astronauts who have flown short duration STS missions on their sleep behaviors and sleep quality on Earth, during training periods, and during Shuttle missions;
(2) Based on an analysis of the data, identify and recommend specific strategies to current and future astronauts for ensuring sleep quality and quantity during spaceflight missions;
(3) Provide recommendations to flight rules and requirements and crew health or habitability standards recommendations for managing sleep-loss related fatigue problems from spaceflight; and,
(4) Assess the feasibility of implementing the full survey instrument, or portions of it, as a standardized operational measure for all spaceflight missions and the information captured in the LSAH.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Deliverable is a report regarding threats to optimal sleep in space, and recommended strategies by shuttle flyers for mitigating these threats.
Internal Customers:
None
External Customers:
Med Ops - Medical Operations
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
VR Enhancing Exercise
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
This task is BHP's participation in SLSD's Innovative Project and its aim is to enhance behavioral health through exercise. A decision point will follow the completion of this task to determine if additional VRs are needed as countermeasures in spaceflight. If so, NRA will follow in FY 13 (touch point with SHFE, HHC, and the Team Risk).
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Summary descriptions of proposed technologies.
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Czeisler, Charles
Short Title:
RCS-105 Photic CM
Responsible HRP Element:
Behavioral Health and Performance
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The success of long-duration missions depends on the ability of the crew to be alert and maintain high levels of cognitive function while operating complex, technical equipment. Optimal human health, performance and safety during spaceflight requires sufficient sleep and synchrony between the circadian pacemaker which regulates the timing of sleep, endocrine function, alertness and performance and the timing of the imposed sleep-wake schedule.
Crew members of the 105-day experiment will be required to work one night shift every fifth night. This schedule will likely result in sleep loss and circadian misalignment, especially when lighting conditions are similar to those experienced during spaceflight. Mission controllers will work 24-hour shifts, also resulting in both sleep loss and circadian misalignment. It has been well documented in laboratory and field studies that both working the night shift and working extended-duration shifts result in negative effects on alertness, performance and mood.
This study will validate the efficacy and operational feasibility of a lighting countermeasure to improve alertness and performance during night-shift work occurring during long-duration space missions.
Specific Aims
1. Evaluate the feasibility of monitoring sleep and circadian neuroendocrine rhythms during the 105-day experiment.
2. Test the hypothesis that sleep, alertness, performance and mood will be impaired during acute circadian misalignment associated with night-shift work operations.
3. Test the hypothesis that alertness, performance and mood of crew members exposed to shorter wavelength light (between 485 to 525 nm) during the night shift in the console monitoring room will be significantly better than when those same crew members are exposed to intermediate (545 to 555 nm) or longer (620 to 690 nm) wavelength light during the night shift.
4. Test the hypothesis that the alertness, performance and mood of the external mission controllers will be impaired during the final third of their extended-duration, 24-hour work shift as compared with the first third of that same work shift.
5. Test the hypothesis that the alertness, performance and mood of external missions controllers exposed to shorter wavelength light during the final third of their extended-duration work shift will be significantly better than when those same crew members are exposed to intermediate or longer wavelength light during the night shift.
Throughout the 105-day experiment, a variety of measurements will be obtained to assess sleep, performance, alignment of the circadian system, and melatonin levels. If a lighting countermeasure proves effective, it could negate or reduce the need for pharmaceutical interventions, with potentially lingering side effects, during long missions. A lighting countermeasure could also be beneficial in other unusual non-24 hour lighting cycles and may negate the effects of fatigue on work performance.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Report on pilot study findings
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Brainard, George
Short Title:
Optimizing Light
Responsible HRP Element:
Behavioral Health and Performance
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
1. Assess the ocular safety of light exposure from LEDs at intensity levels higher than those currently specified for visual stimulation in space habitats.
2. Determine the acute neuroendocrine, alerting, and performance enhancing potency of the ambient extraterrestrial light as filtered through spacesuit visors or glazed windows for Moon and Mars missions. Test the hypothesis that ambient lunar and Martian light, as filtered through spacesuit visors, will suppress melatonin less and will be weaker for enhancing alertness and performance compared to ambient daylight on Earth.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Summary report regarding results of first phase NSBIR investigation. Findings from this investigation and other lighting investigations will inform future protocols for using light as a countermeasure in flight.
Internal Customers:
None
External Customers:
Med Ops - Medical Operations
Is a Customer-Supplier Agreement (CSA) Required?
Yes
Task Book:
Entry
Principal Investigator:
Brainard, George
Short Title:
Blue Light Alertness
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The aim is to study the efficacy of blue-enriched polychromatic solid-state light for acutely enhancing alertness and cognitive performance in healthy men and women.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Summary report regarding results from this investigation. Findings from this investigation and other lighting investigations will inform future protocols for using light as a countermeasure in flight.
Internal Customers:
None
External Customers:
Med Ops - Medical Operations
Is a Customer-Supplier Agreement (CSA) Required?
Yes
Task Book:
Entry
Principal Investigator:
Czeisler, Charles
Short Title:
FMC
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The aim of the investigation is to assess a Comprehensive Police Fatigue Management Program for flight mission controllers. The goals of this program are to reduce the adverse consequences of fatigue on the mission controllers’ alertness, performance, health, and safety. The overall goals include developing an online education training module & an efficient sleep disorders screening, as well as evaluate the acceptability, feasibility and efficacy of a shorter wavelength photic countermeasure and an exercise protocol, during operational night shifts. The results will inform work-hour policies and guidelines that can be implemented to improve the alertness, performance, health, and safety of mission controllers.
This task has been conducted collaboratively with the Mission Operations Directorate.
Other Resources
| Other Resources Needed?
|
Yes
|
Category:
Countermeasure
Subcategory:
Protocol
Description:
Deliverables include countermeasure recommendations for flight controllers, such as education and training.
Internal Customers:
None
External Customers:
MOD - Mission Operations Directorate
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Lockley, Steven
Short Title:
ISS Dynamic Lighting
Responsible HRP Element:
Behavioral Health and Performance
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The current proposal will study how the new lights installed aboard the ISS would be used operationally to address the problems associated with a slam shift, which is a common requirement during ISS operations, in a high-fidelity simulation of the ISS lighting environment, sleep patterns, and work schedule. The study will provide the data necessary to inform the operational guidelines for in-flight testing of the new light source.
Category:
Countermeasure
Subcategory:
Protocol
Description:
a schedule for using various lighting spectrums, intensities, during specific times of day and at phases of a 6-month ISS mission.
Internal Customers:
None
External Customers:
Med Ops - Medical Operations
Is a Customer-Supplier Agreement (CSA) Required?
Yes
Task Book:
Entry
Principal Investigator:
Brainard, George
Short Title:
SSLM
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
1) Build a simulation of the ISS Crew Quarters with both internal and external illumination provided by SSLMs.
2) Run three-day studies with a single volunteer each, collecting data on visual sensitivity, melatonin secretion, subjective alertness, objective alertness, neurobehavioral responses and polysomnography.
3) Analyze the data and write a project report with recommendations based on the pilot study results.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Report regarding study findings and recommendations for future flight study.
Internal Customers:
None
External Customers:
Med Ops - Medical Operations
Is a Customer-Supplier Agreement (CSA) Required?
Yes
Task Book:
Entry Unavailable
Principal Investigator:
N/A
Short Title:
Sleep Workshop
Responsible HRP Element:
Behavioral Health and Performance
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The goal of the workshop will be to pull together the evidence to support: 1) elevation of the Sleep risk posture from green to yellow; 2) inclusion of health outcomes in the Sleep risk title which currently focuses solely on performance); and 3) future collaborations between different disciplines.
The BHP Element is partnering with the National Space Biomedical Research Institute (NSBRI) to conduct this workshop. In addition, BHP plans to collaborate with the Human Health Countermeasures (HHC), Space Human Factors and Habitability (SHFH), and Space Radiation (SR) Elements.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Sleep Workshop will provide a forum for sharing evidence related to sleep, taking inventory of what we know now about sleep in the spaceflight environment, and the latest terrestrial literature related to sleep and health outcomes, to inform future research needs relative to exploration missions. The workshop will also expand the evidence relating to insufficient sleep and health outcomes and will support the expansion of the Sleep risk to include health outcomes, alongside performance.
Internal Customers:
Behavioral Health and Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
Leveton, Lauren
Short Title:
Replacement Lighting
Responsible HRP Element:
Behavioral Health and Performance
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
Transition lighting requirements to the ISS.
Category:
Requirement
Subcategory:
Requirements-Vehicle/Habitat
Description:
Provided technical specifications for replacement lighting on the ISS. Specifications approved by ISS program. Flexible Lighting System to be installed starting in 2015.
Internal Customers:
None
External Customers:
International Space Station (ISS)
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry
Principal Investigator:
Menaker, Michael
Short Title:
Circadian Disruption
Responsible HRP Element:
Behavioral Health and Performance
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
SPECIFIC AIM I: Using rhythms of gene expression reported by a luciferase transgene, we will identify the signals linking brain and peripheral oscillators.
SPECIFIC AIM II: We will evaluate potential countermeasures by exposing our experimental animals to conditions that disrupt the normal circadian phase map and then determining if the potential countermeasures are able to restore it rapidly.
SPECIFIC AIM III: Investigate the effects of chronic low dose methamphetamine in synchronizing disrupted rhythms and evaluate related drugs as potential countermeasures.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Report on circadian countermeasures
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Planned-Funded
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
2022 CVD/Late CNS biomarker & CM ID
Responsible HRP Element:
Space Radiation
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
|
|
Aims:
-
Aim 1 (CVD): Validate surrogate endpoint biomarkers, including standard of care clinical markers, for monitoring space radiation-induced late cardiovascular diseases for use in risk assessment model development and evaluation of protective countermeasures.
-
Aim 2 (Late CNS): Define adverse outcome pathways and potential biomarkers associated with CNS functional changes and late neurodegenerative diseases
-
Aim 3 (CVD): Evaluate standard of care clinical protective measures, such as exercise, dyslipidemia drugs, anti-inflammatory drugs, diet, as mitigation strategy for late cardiovascular diseases.
-
Aim 4 (late CNS): Determine whether CVD countermeasures are effective in mitigating adverse CNS effects.
Category:
Countermeasure
Subcategory:
Clinical Procedure/Prescription
Description:
Validated standard of care countermeasures effective in mitigating radiation-induced CVD and late neurodegenerative diseases.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
2026 CVD/Late CNS biomarker & CM Val
Responsible HRP Element:
Space Radiation
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
|
|
Aims:
-
Aim 1 (CVD): Validate efficacy of standard of care clinical protective measures in a combined stressor model with chronic mixed field exposures, evaluating for mitigation of radiation-induced CVD.
-
Aim 2 (CVD/CNS): Validate efficacy of cross-risk candidate radioprotective agents in a combined stressor model with chronic mixed field exposures, evaluating for mitigation of radiation-induced CVD and late CNS adverse outcomes.
-
Aim 3 (CVD, CNS): Evaluate any potential antagonistic, synergistic, or additive effects across CVD protective measures and late CNS adverse outcomes.
Category:
Countermeasure
Subcategory:
Clinical Procedure/Prescription
Description:
Validated medical countermeasures to mitigate CVD and late neurodegenerative diseases from the combined stressors of spaceflight.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
Acute CNS-BCM 2024 to 2028
Responsible HRP Element:
Space Radiation
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
|
|
Aims:
Aim 1: Evaluate radioprotective strategies for acute CNS effects.
Aim 2: Quantify impact of exercise, sleep as protective measures to mitigate acute CNS risks.
Aim 3: Validate radioprotective strategies in animal models in compliance with FDA animal rules.
Aim 4: Validate risk models.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual and final reports.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
CBS CM2 Review/Trade Study
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
|
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
|
|
Aims:
This study builds on CM1 Trade Study (above) to provide ground development and validation of CMs to counter synergistic effects on identified risk areas. This study applies the results of the CBS Integrated Risk Trade Study and initial CM1 research, with those results now further refining and guiding researh heuristics from ground-validation, with finalization of the most technically acceptable, feasible and scientifically valid countermeasures from transdisciplinary perspective.
Category:
Countermeasure
Subcategory:
Description:
-Recommendations to inform solicitation for CM2 update
-Integration of ground validated research and the basis for recommendation for pre-, in-, and/or post-flight countermeasures required for CBS Integrated Risk and CM2. .
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
CBS CM1 Review & Trade Study
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
|
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
|
|
Aims:
Conduct CBS Integrated Risk Trade Study, taking into account feasibility, maturation, cost, etc., using informational framework similary to IOM-style review (i.e., with a focus on level and quality of evidence). This Trade Study will serve as a decision-making activity to identify the most technically acceptable, feasible and scientifically valid countermeasures from transdisciplinary perspective and from among those identified for single and integrated risks.
Potential solutions of a trade study are judged by their overall satisfaction of a series of desirable characteristics. These characteristics may conflict with one another or even be mutually exclusive.
Category:
Countermeasure
Subcategory:
Description:
-Recommendations to inform solicitation for initial development and validation of CBS Integrated Risk consolidated Countermeasures (CM1).
-Trade Study results that provide an effective means for addressing CBS Integrated Risk CMs with documentation of the evaluation and decision-making process to ensure traceability and repeatability of those CMs recommended and why in order to judge the overall satisfaction against a series of identified desirable characteristics of CMs (highlighting those characteristics that may conflict with one another or that might be mutually exclusive).
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
CBS CM2 Human Flight Update/Validation
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
|
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
|
|
Aims:
Identification & validation of countermeasure (CM) development integrating refinements from space radiation exposures in rodent & NHP research that identified specific Brain Performance Pathway (BPP) regions with targeted CMs to reduce vulnerability/risk of decrements in operationally-relevant crew health and performance in the sensorimotor, behavioral, and cognitive domain areas linked to mission duration and success. Incorporate flight data to integrate refinements from CBS research with identified specific brain regions and biomarkers linked with spaceflight hazard induced performance-relevant neural processes and interventions to mitigate those risks.
Category:
Countermeasure
Subcategory:
Description:
-Ground & Flight validated recommendations for update to pre-, in-, and/or post-flight operationally-relevant countermeasures linked to methods (i.e., biomarkers) to identify both need for and results of CM interventions
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
CBS CM1 Devel/Validation (Nutrition/Biomarker Signaling)
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
|
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
|
|
Aims:
This study builds on CM1 Trade Study (above) to provide ground development and validation of CMs to counter synergistic effects on identified risk areas. This study applies the results of the CBS Integrated Risk Trade Study, with those results now serving to guide research heuristics in an effort to identify and ground-validate the most technically acceptable, feasible and scientifically valid countermeasures from transdisciplinary perspective.
Category:
Countermeasure
Subcategory:
Description:
-Ground validated research basis for recommendation for pre-, in-, and/or post-flight countermeasures required for CBS Integrated Risk.
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
CBS Data Mining CMs: Fam Hist/Prev Med/Individual Sensitivities/Exposures/Monitoring Exposures
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
|
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
|
|
Aims:
Robust identification of current research that identifies both pre-mission risks and vulnerabilities for individuals due to family history, previous exposures, preventive medicine, sensitivites, genotype and phenotype within the context of integrated risk and risks posed to crew health and safety and the countermeaaures needed should medical conditions arise. For example, in major depressive disorder, high levels of histone deacetylase 5 prior to treatment initiation appear to be a robust marker for treatment response (Iga et al., 2007; Hobara et al., 2010; Belzeaux et al., 2010). Levels of cyclic-adenosine monophosphate (cAMP) response element binding protein 1 (Iga et al., 2007), histone deacetylase 2 (Hobara et al., 2010), serotonergic markers (Belzeaux et al., 2010), a panel of four gene expression pro les (Belzeaux et al., 2012), and interferon regulatory factor 7 (Mamdani et al., 2011) have variously been reported to change following treatment with antidepressants.
-Belzeaux R, Formisano-Tre´ziny C, Loundou A, Boyer L, Gabert J, Samuelian JC, Fe´ron F, Naudin J, Ibrahim EC (2010) Clinical variations modulate patterns of gene expression and de ne blood biomarkers in major depression. J Psychiatr Res 44:1205–1213.
-Belzeaux R, Bergon A, Jeanjean V, Loriod B, Formisano-Treziny C, Verrier L, Loundou A, Baumstarck-Barrau K, Boyer L, Gall V, Gabert J, Nguyen C, Azorin JM, Naudin J, Ibrahim EC (2012) Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode. Transl Psychiatry 2:e185.
-Hobara T, Uchida S, Otsuki K, Matsubara T, Funato H, Matsuo K, Suetsugi M, Watanabe Y (2010) Altered gene expression of histone deacetylases in mood disorder patients. J Psychiatr Res 44:263–270.
-Iga Ji, Ueno Si, Yamauchi K, Numata S, Kinouchi S, Tayoshi- Shibuya S, Song H, Ohmori T (2007) Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression. Prog Neuropsychopharmacol Biol Psychiatry 31:628–632.
-Mamdani F, Berlim MT, Beaulieu MM, Labbe A, Merette C, Turecki G (2011) Gene expression biomarkers of response to citalo- pram treatment in major depressive disorder. Transl Psychiatry 1:e13.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
'-Identification of knowledge gaps for countermeasures (CMs) with respect to synergistic impacts of space radiation in isolated & confined environments (Behavioral Medicine, BMed) and altered gravity where sensorimotor (SM) risks are encountered
-Individual sensitivities to each risk (space radiation, isolation & confinement, and microgravity) and responsiveness to CMs delivered to counter the changes (adaptations) to those risks
-Potential differences in SM/BMed Brain Performance Pathways differentially affected by space radiation exposures
-Identification and development of a standardized protocol that is strictly adhered to keep variation to a minimum and that encompasses sample collection, storage, processing, and marker measurement to retain the integrity of the test (Dean, 2011).
-Identification of potential SM/BMed countermeasures based on vulnerabilities & sensitivities.
--Dean B (2011) Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studies. Int J Neuropsychop 14:997–1012.
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
CBS NSCOR #1: CBS Synergistic Effects Study - Dose Effect/CM
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
|
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
|
|
Aims:
NSCOR with multiple research arms with GCRsim mixed field as core with experimental design to assess "leveraging previous research focused synergistic, order-effects of radition exposure (RE), isolation & confinement stress (ICS), and SM (hindlimb unloading), using standardized handling and behavioral tests, biomarker changes, and brain physiology changes that predict changes in operationally-relevant brain performance pathways.
Category:
Technology or Tool
Subcategory:
Description:
-Predictive models for brain pathways affected by radiation, stress, altered gravity
-Mapping of compensatory pathways
-Dose effects of risk exposures
-Countermeasures (CMs)
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
CBS Research Integration
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
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| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
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Funding Status:
Planned-Funded - Task expected to be within budget
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Procurement Mechanism(s):
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Aims:
Ongoing review/dissemination of results from current space radiation (SR) research as studies complete. Focus is on identifying, evaluating, clarifying, and integrating relevant past research from CBS risk areas (i.e., CNS, Bmed, & SM) in order to refine subsequent research inquiries and emphases. Systematic, scoping review of past research in three risks of CBS risk areas to clarify and integrate the research into operationally-relevant performance areas; balance the feasibility and acceptability of research to date in addressing operational performance constructs, identify iterative processes to select relevant research to extract data to incorporate into a thematic analysis and implications of research to date as it relates to standards and performance and countermeasure development. Assess and define the methodological rigor used and needed to determine quality of research and to formalize knowledge translation between the three risks into an integrated approach.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
-CBS Integrated Research Report summarizing the extent, range, and nature of three (CNS, BMed, & SM) research activities that considers the rationale for integrated approach and implications related to operational performance and impact on research, practice, and development/refinement of relevant standards.
-Assess methodological quality of included studies.
-Summarize and disseminate research findings.
-Identify research gaps in the existing literature:
-Mechanisms
-Pathways
-Order effects validation
-Biomarkers
-Countermeasures
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
CBS RR: HCAAM Intelligent System: Monitoring & CMs Performance Pathways
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
|
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
|
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Aims:
-Conduct Research Review focused on potential human system adaptations with autonomous systems and habitat in order to maintain operationally-relevant performance by leveraging both countermeasures (CM) and Human Capabilities Assessment for Autonomous Missions (HCAAM) Intelligent System that monitors Brain Performance Pathways and then responds with appropriate countermeasures to mitigate risk and/or compensate for decrements in performance throughout mission.
Category:
Study Results
Subcategory:
Customer Requested Study or Analysis
Description:
-Research Review report that evaluates potential decrements and human capabilities, with focus on potential human system adaptations with autonomous systems and habitat in order to maintain operationally-relevant performance by leveraging both CM's and Human Capabilities Assessment for Autonomous Missions (HCAAM) Intelligent System that monitors Brain Performance Pathways.
-Report evaluates and recommends CMs to mitigate risk and/or compensate for decrements in performance throughout mission.
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
CBS Stress Response, Cross-species Homology Study NHPs
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
|
Funding Status:
Planned-Funded - Task expected to be within budget
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Procurement Mechanism(s):
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Aims:
Research project focused on developing scientifically plausable, heuristic, computational models using Non-Human Primates (NHP) and radiation exposures (both clinical and space relevant, in combination with other CBS realted spaceflight stressors) in order to assess, characterize and derive and valdiate operationally-relevant models of performance outcome levels relative to radiation exposures (in combination with other CBS realted spaceflight stressors), dose effects and countermeasures for CBS integrated risk exposures in humans. An important aspect of this effect involves the conceptualization of research that is "reverse translation" in which consideration is given to the specific biological markers with significant operationally-relevant performance consequences are first determined in human models and then applied to an animal model to see if they exist and that they reflect the same performance decrements as evidenced in humans. This approach will facilitate the identification of novel biomarkers linked to different levels of performance (impact by CBS synergistic risks) with the introduction of CBS integrated risk at different stages of mission-relevant performance demands in the animal models. This also offers the potential to identify biomarkers related to the brain performance pathways.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
-Integrated stress response linked to outcome measures
-Cross-species homology of selected outcome measures
-Identify early markers of molecular and/or cellular changes in order to elucidate the molecular cascades linked to performance outcomes changes that result from the synergistic CBS risks.
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
CM Validation II
Responsible HRP Element:
Space Radiation
Funding Status:
Planned-Funded - Task expected to be within budget
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Procurement Mechanism(s):
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Aims:
Studies to validate identified medical countermeasures that address multiple tumor types and multiple risk areas (i.e., cancer, late neurodegeneration, cardiovascular disease) with the following aims:
Specific Aims:
-
Aim 1 (Cross Risk): Validate efficacy of candidate countermeasure agents in additional model systems in compliance with FDA animal rules.
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Aim 2 (Cross Risk): Validate efficacy of candidate countermeasure agents in space relevant environment.
-
Aim 3 (Cross Risk): Determine minimum dosing (mg/day) requirements for optimum effectiveness.
-
Aim 4 (Cross Risk): Evaluate any potential antagonistic effects across space radiation risk area endpoints including multiple tumor types
-
Aim 5 (Cross Risk): Evaluate biomarker approaches to assess countermeasure efficacy for surveillance, treatment, and outcome prediction.
Category:
Countermeasure
Subcategory:
Clinical Procedure/Prescription
Description:
Validated medical countermeasures with broad range of action across radiation-induced endpoints.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
Computational Modeling for CBS Synergistic/Order Effects of Spaceflight Hazards
Responsible HRP Element:
Human Factors and Behavioral Performance
|
Collaborating Org(s):
|
| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
|
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
|
|
Aims:
This CBS Integrated Research topic is proposed to assemble a multidisciplinary team into an “integrated” Virtual NSCOR with multiple research arms that use GCRsim mixed field as the core with experimental design and with translational conceptualizations that leverage the Research Domain Criteria (RDoC) to provide computational model to characterize and predict changes in operationally-relevant Brain Performance Pathways using animal models to assess distinct processes of cognitive and behavioral changes of relevance to operationally-relevant performance, linking neural processes and biomarkers to these constructs in order to assess synergistic and order-effects of radiation exposure (RE), isolation & confinement stress (ICS), and SM (hindlimb unloading), using standardized handling and behavioral tests, brain physiology changes (to include Blood-Brain-Barrier changes), molecular signaling with biomarker changes. This approach is also intended to help develop the framework for performance outcome limits and determine more targeted countermeasures for intervention.
Category:
Technology or Tool
Subcategory:
Description:
-Predictive models for Brain Performance Pathways (with mapping to compensatory pathways) affected by space-like radiation, stress, and altered gravity
-Identification of integrative dose-effects, along with mapping of compensatory pathways and adverse outcome pathway heuristic computational modeling and countermeasures
-Heuristic model of performance decrements linked to neural processes and biomarkers
-Proposed model/framework for identifying POLs
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
Cross Risk Countermeasures II
Responsible HRP Element:
Space Radiation
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
|
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Aims:
Research will evaluate medical countermeasures that mitigate risk of radiation induced diseases addressing multiple tumor types and multiple risk areas (i.e., cancer, late neurodegeneration, cardiovascular disease) including the:
-
Mitigation of solid and hematologic cancers due to space radiation exposure as measured by incidence, aggressiveness, overall burden, and time to occurrence.
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Mitigation of cardiovascular disease incidence, latency, and progression as measured by clinical outcomes, events, pathology and survival times.
Specific Aims:
-
Aim 1 (Cross Risk): Identify and prioritize candidate cross-risk countermeasure agents targeting common pathways of adverse outcomes from space radiation exposure
-
Aim 2 (Cross Risk): Using appropriate animal models, test efficacy of selected medical countermeasures for prevention of adverse outcomes across multiple risk areas following simulated GCR and SPE exposures.
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Aim 3 (Cross Risk): Identify potential cross-risk and cross-element antagonistic countermeasure approaches
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Aim 4 (Cross Risk): Identify biomarker approaches to assess countermeasure efficacy for surveillance, treatment, and outcome prediction.
Category:
Countermeasure
Subcategory:
Clinical Procedure/Prescription
Description:
Identification of medical countermeasures with broad range of action across radiation-induced endpoints.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
Family and Social Support
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
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Aims:
Long duration exploration missions will require extended separation from a crewmember’s family and friends, which can negatively impact crew health and performance. Current methods and technologies are likely insufficient to support future long duration autonomous crews. This task will be a research study to develop and test the feasibility, acceptability, and effectiveness of a protocol of a pre-, in- and, post- flight support including family and non-family social support for the promotion of astronaut behavioral health.
This task will contribute to gap closure by providing recommendations/requirements for an effective psychosocial support system that replicates what is currently available and acceptable for ISS crewmembers but is feasible for exploration class missions.
Ground Analog Resources
| Ground-Based Flight Analogs
|
TBD
|
| Number of Subjects
|
0
|
Category:
Countermeasure
Subcategory:
Protocol
Description:
Protocol of pre-, in-, and post-flight support including family and non-family social support for the promotion of astronaut behavioral health and wellbeing.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
Med Ops - Medical Operations
Office of the Chief Health and Medical Officer (OCHMO)
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
Inter-Agency MCM Studies
Responsible HRP Element:
Space Radiation
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
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Aims:
Specific Aims:
-
Aim 1: Identify and prioritize candidate radioprotective and chemopreventive agents to mitigate radiation health risks
-
Aim 2: Perform preliminary countermeasure evaluation using radioprotective/chemopreventive agents that target common pathways of radiation induced injury (e.g. inflammation).
-
Aim 3: Test efficacy of selected medical countermeasures in space relevant environments.
Category:
Countermeasure
Subcategory:
Clinical Procedure/Prescription
Description:
Screening/efficacy testing of early candidate countermeasures
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
ISS HRP Spaceflight Exploration Measures (HFBP) for Mars Fly-By
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
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Aims:
This will allow HRP to establish, evaluate, and manage a common set of measures for use in spaceflight and analog research to: develop baselines, systematically characterize risk likelihood and consequences, and assess effectiveness of countermeasures that work for human factors and behavioral performance risk factors. This task will provide “standard measures” as the foundation to achieve consistent research measures for data-sharing in ISS and to meet the highly constrained, operationally-focused data gathering and analysis that allows for greater consistency in the research methods that are very specific to NASA HRP standard measures development. Additionally, the set of standardized measures on the ISS reflects the more operational nature of the measures while allowing the multiple and frequent internal and external collaborations required to execute this study.
Aims:
1. Provide a set of standard measurements from HFBP towards the HRP standard measures for investigators to use in proposed projects.
2. Enable comparison of multiple missions across spaceflight analog campaigns to quantify risk using reliable metric-based data.
3. Provide database for data-mining and integrative modeling and increase research data quality and transfer to LSDA.
This task will contribute to gap closure by facilitating all tasks using ISS in the BMed, Sleep, and Team risk areas and by testing measures and monitoring tools for the Mars Fly-by.
Category:
Technology or Tool
Subcategory:
Informatics
Description:
Standardized data across the BMed, Team, and Sleep risks for ISS to be deposited into the LSDA and shared with other ISS Investigators, including use for future data-mining.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
Problem Solving Skills Training
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
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Aims:
NASA’s “mission teams” are composed of astronauts and Earth-based support staff (flight crews, Mission Control Center, flight controllers, flight control teams, etc.) who work closely together to ensure both individual and crew performance. Future Long Duration Spaceflight Exploration (LDSE) missions, potentially including planetary surface missions on Mars, will demand the support and ability of these teams to manage shifting levels of autonomy when crew health, performance and/or mission success are threatened by unanticipated problems.
This task will provide standards and guidelines for training individual and team problem-solving skills across all team, medical, and technical domains for both work and non-work situations throughout a long-duration mission.
1. Determine how problem-solving skills are developed and used in operational settings such that there is generalization across many tasks and situations.
2. Identify which individual and team skills are most important to performing tasks in normal conditions and surviving in emergency conditions for LDEM.
3. Determine the relationship of individual cognitive processes/skills (e.g., attention, reasoning) to team cognitive processes/skills (e.g., collaborative problem solving, decision making).
4. Describe how these skills change over time and what may trigger these shifts.
5. Validate measurement, particularly unobtrusive measurement, of these skills for both individuals and teams.
6. Develop validated training guidelines and recommendations to develop and maintain individual and team cognitive skills throughout an LDSE mission, and allow them to be trained efficiently to maintain performance across tasks and situations in mission.
Ground Analog Resources
| Ground-Based Flight Analogs
|
Controlled Research Analog, Long Duration (4 months or more) – isolated and confined with spaceflight mission scenario [e.g., NEK/Russian Chamber]
|
| Number of Subjects
|
0
|
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Risk characterization describing which individual and team skills related to problem-solving are most important in both nominal and off-nominal tasks/situation, how these skills may generalize across tasks/situations, and how these skills change over time and, if so, what may trigger these shifts.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Standard
Subcategory:
Update
Description:
Standards and Guidelines recommendations related to training and other countermeasures to develop and maintain individual and team problemsolving skills
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Countermeasure
Subcategory:
Protocol
Description:
Corresponding countermeasure prototypes and training protocols supporting the recommended Standards and Guidelines.
Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Task Book:
Entry Unavailable
Principal Investigator:
TBD
Short Title:
Habitability and Sensory stimulation for LDM
Responsible HRP Element:
Human Factors and Behavioral Performance
Funding Status:
Planned-Funded - Task expected to be within budget
|
Procurement Mechanism(s):
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Aims:
The focus of this effort is to provide environmental/habitat countermeasures for habitat design, to promoting sensory stimulation through environmental enrichment, adaptable interfaces, and optimizing sensory modalities, to target changes in brain plasticity and performance.
Category:
Countermeasure
Subcategory:
Protocol
Description:
Protocol to provide environmental and habitat countermeasures to promote sensory stimulation that target brain performance.
Internal Customers:
None
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Documentation:
No Documentation Available