Funding Status:
Active - Currently funded and in progress
Procurement Mechanism(s):
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Aims:
Aim 1 will simulate a 6 month ISS human mission, determining the impact of simulated
weightlessness and space radiation [150 MeV protons (20 mGy), 1 GeV protons (20 mGy) and
600 MeV/n silicon (10 mGy)] on cardiac rhythm and risk for cardiac disease.
Specific Aim 2 will simulate a 3-3.5 year deep space human mission, determining the impact
of simulated weightlessness combined with components of galactic cosmic rays (60 % 1 GeV
protons, 20% 250 MeV/n helium, 10% 350 MeV/n oxygen and 10% 600 MeV/n silicon) with
total doses of 0.50 and 0.75 Gy plus appropriate controls on cardiac rhythm and risk for
cardiac disease.
Specific Aim 3 will determine the response to gamma radiation with and without simulated
weightlessness, to estimate relative biological effectiveness (RBE) for early clinically relevant
endpoints for cardiac rhythm and risk for cardiac disease. Rats will be irradiated with doses of
0.25, 0.5 Gy, 1.0 Gy and 2.0 Gy of 137Cs at Brookhaven National Laboratory alongside
experimental animals.