Gap CVD-201: Select countermeasures and procedures to be tested based on previous objectives.
Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Present state of knowledge: Mitigation of cardiovascular disease risk factors associated with spaceflight exposure (e.g., reduced physical activity, poor dietary habits, circadian dysregulation, impaired sleep, immune dysregulation, psychological stress, elevated levels of oxidative stress, and inflammation) would be appropriate avenues to control the risk of cardiovascular disease during and after spaceflight. Current astronaut and flight selection criteria aim towards reducing the risk of a cardiovascular event due to preflight conditions; cardiovascular health risks are managed on the ground to prevent in- and postflight occurrences. In addition to the inflight habits encouraged during spaceflight (e.g., exercise, appropriate dietary choices, improved sleep habits, managing psychological stress), countermeasures to consider might include interventions that have shown to be effective in ground-based research such as sulfhydryl or thiol compounds, anti-oxidants, anti-inflammatories, and cholesterol lowering medications (e.g., statins and γ-tocotrienol). Currently no medical countermeasures have been validated to mitigate the long-term cardiovascular effects of the chronic low dose-rate mixed field irradiation experienced in the spaceflight environment, but a variety of potential countermeasures are available that can be tested in the context of space radiation exposures. Selected countermeasures need to be both effective at reducing cardiovascular risk and safe for implementation in a healthy astronaut population.

Research approach
: Data mining, conferences, literature review, the NASA process of Request For Information (RFI), and workshops with key experts. Ground-based research to identify common pathway targets and metrics to monitor efficacy to support candidate countermeasure selection.
Target for Closure
Selection of candidate countermeasures to be tested in ground analogs as well as during spaceflight conditions.
  • Identify metrics to monitor efficacy of countermeasures
  • Identify common pathway targets for countermeasure selection
Risk Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
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Multi-Disciplinary Research Plans

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