Last Published:  07/30/20 02:45:13 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Description
Present state of knowledge: Mitigation of cardiovascular disease risk factors associated with spaceflight exposure (e.g., reduced physical activity, poor dietary habits, circadian dysregulation, impaired sleep, immune dysregulation, psychological stress, elevated levels of oxidative stress, and inflammation) would be appropriate avenues to control the risk of cardiovascular disease during and after spaceflight. For example, in a bed rest model, exercise alone was able to prevent carotid artery remodeling that was present in control subjects who performed no exercise. In addition to the inflight habits encouraged during spaceflight (e.g., exercise, appropriate dietary choices, improved sleep habits, managing psychological stress), countermeasures might include dietary and pharmacological interventions that have shown promise in ground-based research, such as sulfhydryl or thiol compounds, anti-oxidants, anti-inflammatories, and cholesterol level-modifying medications (e.g., statins and γ-tocotrienol).

Research approach
: Testing effects of countermeasures (e. g. anti-oxidants, pharmaceuticals, nutrition) in rodents and larger animals during suspension combined with NSRL radiation.
Target for Closure
Understanding which countermeasures are effective and, when possible, test synergistic effects of multiple countermeasures. The purpose is to understanding which countermeasure combinations will be operationally-feasible during spaceflight.
  • Validation of countermeasures in a chronic mixed field environment in accordance with the FDA Animal Rule.
  • Evaluation of countermeasures in a combined stressors model in a chronic mixed field environment.
Mappings
Risk Risk of Spaceflight Induced Cardiovascular Disease
You are here! Gap CVD-202: Ground-based development and testing of countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.
Active
Completed
Planned-Funded

Documentation:
No Documentation Available