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Gap CV-202: Develop and ground-test countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.
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Last Published:  07/29/22 01:33:20 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Description
Present state of knowledge: Mitigation of cardiovascular disease risk factors associated with spaceflight exposure (e.g., reduced physical activity, poor dietary habits, circadian dysregulation, impaired sleep, immune dysregulation, psychological stress, elevated levels of oxidative stress, and inflammation) would be appropriate avenues to control the risk of cardiovascular disease during and after spaceflight. For example, in a bed rest model, exercise alone was able to prevent carotid artery remodeling that was present in control subjects who performed no exercise. In addition to the inflight habits encouraged during spaceflight (e.g., exercise, appropriate dietary choices, improved sleep habits, managing psychological stress), countermeasures might include dietary and pharmacological interventions that have shown promise in ground-based research, such as sulfhydryl or thiol compounds, anti-oxidants, anti-inflammatories, and cholesterol level-modifying medications (e.g., statins and γ-tocotrienol).

Research approach: Testing effects of countermeasures (e. g. anti-oxidants, pharmaceuticals, nutrition) in rodents and larger animals during suspension combined with NSRL radiation.
Target for Closure
Understanding which countermeasures are effective and, when possible, test synergistic effects of multiple countermeasures. The purpose is to understanding which countermeasure combinations will be operationally-feasible during spaceflight.
  • Validation of countermeasures in a chronic mixed field environment in accordance with the FDA Animal Rule.
  • Evaluation of countermeasures in a combined stressors model in a chronic mixed field environment.
Mappings
Risk Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
You are here! Gap CV-202: Develop and ground-test countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.
Active
Task Attenuation of Space Radiation-induced Pro-oxidant and Fibrotic Signaling in the Heart by Nutritional and Genetic Interventions: Adventures in Tissue Sharing
Completed
Completed Task Center for Research on Cardiac and Vascular Effects of Space Radiation
Completed Task Candidate nutritional countermeasure to mitigate adverse effects of spaceflight (Schreurs)
Completed Task Mitigating radiation-induced bone loss via dietary modulation of inflammatory cytokines (Bloomfield)
Planned-Funded
Task 2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

Multi-Disciplinary Research Plans

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