Gap Cancer-402: Identify and/or develop monitoring tools to support spaceflight research, long-term health surveillance, and countermeasure implementation.
Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Space Radiation (SR)
Status: Open
Description

One of the  threats to astronaut health associated with Mars missions is the distance from Earth. Unlike ISS or Lunar missions, the ability to return crew for robust medical treatment is impossible. The capability to assess an astronaut’s individual susceptibility prior to flight, monitor astronaut health in-mission, predict and monitor astronaut health post-flight, and provide an avenue for early detection of high risk cancers and other degenerative effects across astronaut lifespan is important to minimize the long term health consequences of space radiation exposure and inform standard of care. Therefore, identification and validation of new and emerging biomedical approaches for early detection and treatment of pre-malignant tissues is necessary for the surveillance of astronaut health over their lifetimes (including pre-flight, in-mission, and post-flight) and assessment of risks to long term health pre-flight, in-mission, and post-flight remains a paramount endeavor.

Approach

Datamining and ongoing technology surveillance of both animal and human clinical data, tech watches, interagency collaboration for identification of potential biomarkers. Ground-based research using in vitro and in vivo models as well as systems biology approaches to leverage animal and clinically relevant human datasets to assess and validate novel biomarkers for personalized risk assessment, disease monitoring, and countermeasure development and testing.

Target for Closure
  • Identify a comprehensive range of effective health monitoring/screening approaches.
  • Initial recommendations for clinical practice guidelines as well as biomarkers to incorporate into standard measures for future missions.
  • Incorporation of efficacy of monitoring tools into computational model systems to assess changes in risk.
Mappings
Risk Risk of Radiation Carcinogenesis
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Multi-Disciplinary Research Plans

Documentation:
No Documentation Available