Gap Cancer-602: Operationalize identified and validated interventional countermeasures for space flight.
Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Space Radiation (SR)
Status: Open
Description

The identification and validation of interventional countermeasures for safety and efficacy at reducing the long-term carcinogenesis risk from space radiation exposure is only the first step towards full implementation for spaceflight. Additional factors including, but not limited to, drug stability in the spaceflight environment, mass and volume for storage, drug delivery, and the environmental fate of metabolites in a closed and confined system, must be taken into account before an interventional countermeasure can be operationalized for use in the astronaut corps. Therefore, research in collaboration with operations is required to validate the safety, resilience, and optimal use of interventional countermeasures.

Approach

Guidance from advisory boards/panels and working groups that integrate spaceflight research and operations relevant to crew health. 

Target for Closure
  • Develop plan for testing interventional countermeasures to determine implementation feasibility in astronaut population including efficacy in reducing radiation-induced carcinogenesis, ease-of-use, use in healthy populations, stability, and feasibility for long duration missions.
  • Operationalize interventional countermeasures for spaceflight (if applicable).
  • Comprehensive countermeasure strategy for intervention of long-term health risks associated with radiation exposure.
  • Updated recommendations for clinical practice guidelines incorporating use of validated countermeasure toolkit.
  • Fitness for Duty Standard recommendations
Mappings
Risk Risk of Radiation Carcinogenesis
You are here! Gap Cancer-602: Operationalize identified and validated interventional countermeasures for space flight.

Multi-Disciplinary Research Plans

Documentation:
No Documentation Available