Task Pilot Studies of Radiation Damage in Organ Tissues of Mice (Completed)
Last Published:  07/29/22 01:33:24 PM (Central)
Short Title: Radiation Damage in Mice
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Space Radiation (SR) Element
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
The aims of this pilot study are to examine the sensitivity of bone cells and tissue of C57BL/6 mice to acute high dose gamma radiation (6Gy dose of Cs-137 gamma rays) and the ability of low dose (50 mGy) radiation to mediate the effects of radioprotection.

Aim 1: Characterize the effect of a low, high and combined dose exposures in bone marrow tissue of vertebral bodies and proximal tibia, two tissues of different turnover rates.  Measured indices include: cancellous bone volume, trabecular bone architecture, bone marrow cell density, bone cell numbers(osteoclasts and osteoblasts) and/or surface-based indices of bone turnover.

Aim 2: Characterize the effects of Aim 1 for varying time periods following exposure to high dose.

Integration/Unique Aspects: This pilot study "Radioadaptive response in animals: A pilot study to evaluate effects in bone tissue" is an add-on to a DOD-funded proposal awarded to Dr. Honglu-Wu in Radiation Element.