Short Title:
Radiation Damage in Mice
Responsible HRP Element:
Human Health Countermeasures
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Collaborating Org(s):
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| Space Radiation (SR) Element |
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Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
The aims of this pilot study are to examine the sensitivity of bone cells and tissue of C57BL/6 mice to acute high dose gamma radiation (6Gy dose of Cs-137 gamma rays) and the ability of low dose (50 mGy) radiation to mediate the effects of radioprotection.
Aim 1: Characterize the effect of a low, high and combined dose exposures in bone marrow tissue of vertebral bodies and proximal tibia, two tissues of different turnover rates. Measured indices include: cancellous bone volume, trabecular bone architecture, bone marrow cell density, bone cell numbers(osteoclasts and osteoblasts) and/or surface-based indices of bone turnover.
Aim 2: Characterize the effects of Aim 1 for varying time periods following exposure to high dose.
Integration/Unique Aspects: This pilot study "Radioadaptive response in animals: A pilot study to evaluate effects in bone tissue" is an add-on to a DOD-funded proposal awarded to Dr. Honglu-Wu in Radiation Element.
Other Resources
| Other Resources Needed?
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Yes
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Category:
Technology or Tool
Subcategory:
Informatics
Description:
This Task contributes to Gap closure by investigating, in an animal model, the effects of induced radiation damage on tissue across disciplines, which cannot be ethnically studied in a human model.
Internal Customers:
None
External Customers:
None