Task Mechanisms of Cell Survival Following Space Radiation-Induced Mitotic Catastrophe: Implications for Cancer Risk (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Cell Survival
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. The principal goal of the present application is to test the hypothesis that cells undergoing mitotic catastrophe (MC-- these cells are large multinucleated, polyploid cells) after exposure to charged particle radiation are able to escape death, to undergo depolyploidization, to give rise to a cell progeny of small mononucleated cells that regain a degree of genomic stability sufficient for them to survive, to proliferate, to acquire transformation competence, and thus to become a focal spot for cancer initiation.

 

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