Task NSCOR: Mechanisms Underlying the Risk of HZE Particle-Induced Solid Tumor Development (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: HZE Particle-Induced Solid Tumor Development
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Determine whether the lung cancer suppressors, Gprc5a and p53, protect against HZE particle-induced lung carcinogenesis, and whether miR-21 overexpression blunts this protective effect.
  2. Determine whether HZE-particle radiation exposure results in hyper-reliance on error-prone DNA repair pathways, whether miR21 mediates this effect, and whether dysregulation of DNA repair contributes to lung carcinogenesis.
  3. Determine the nature of the HZE-particle induced ROS stress response, whether it contributes to HZE particle-induced lung carcinogenesis, and the role of miR-21 in this process.
  4. Determine the scope of HZE-particle radiation-induced alterations in DNA methylation patterns, whether these alterations contribute to lung carcinogenesis, and the role of miR-21-dependent targeting of DNA methyltransferase 1 (DNMT1) in this process.
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