Short Title:
HZE Particle-Induced Solid Tumor Development
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
- Determine whether the lung cancer suppressors, Gprc5a and p53, protect against HZE particle-induced lung carcinogenesis, and whether miR-21 overexpression blunts this protective effect.
- Determine whether HZE-particle radiation exposure results in hyper-reliance on error-prone DNA repair pathways, whether miR21 mediates this effect, and whether dysregulation of DNA repair contributes to lung carcinogenesis.
- Determine the nature of the HZE-particle induced ROS stress response, whether it contributes to HZE particle-induced lung carcinogenesis, and the role of miR-21 in this process.
- Determine the scope of HZE-particle radiation-induced alterations in DNA methylation patterns, whether these alterations contribute to lung carcinogenesis, and the role of miR-21-dependent targeting of DNA methyltransferase 1 (DNMT1) in this process.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual Report
Internal Customers:
None
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual and Final Reports
Internal Customers:
None
External Customers:
None