HRR - Task - Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

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Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms (Completed)

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry
Principal Investigator: Globus, Ruth

Short Title: 0g SR Bone

Responsible HRP Element: Space Radiation

Collaborating Org(s):

National Space Biomedical Research Institute (NSBRI)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

To test the hypothesis that simulated weightlessness of mice modulates the response of bone and bone marrow to radiation, both acutely and during tissue regeneration.
To identify the target marrow-derived stem, progenitor and differentiated cell populations sensitive to the combined stimuli of simulated weightlessness and radiation.
To explore the relevance of specific ROS/RNS and p53-dependent mechanisms for mediating cellular responses to combined simulated weightlessness and radiation.

Resources (None Listed)

Deliverables (1)

Mappings

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Related Tasks (186)

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Risk Approach Plans (3)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.