Task Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms (Completed)
Last Published:  07/29/22 01:33:24 PM (Central)
Short Title: 0g SR Bone
Responsible HRP Element: Space Radiation
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
  1. To test the hypothesis that simulated weightlessness of mice modulates the response of bone and bone marrow to radiation, both acutely and during tissue regeneration.
  2. To identify the target marrow-derived stem, progenitor and differentiated cell populations sensitive to the combined stimuli of simulated weightlessness and radiation.
  3. To explore the relevance of specific ROS/RNS and p53-dependent mechanisms for mediating cellular responses to combined simulated weightlessness and radiation.


Resources (None Listed)