HRR - Task - Two-Hit Model of Alzheimer's Disease

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Two-Hit Model of Alzheimer's Disease (Completed)

Last Published: 03/26/21 03:34:00 PM (Central)

Task Book: Entry
Principal Investigator: Zhu, Xiongwei

Short Title: Two-Hit Alzheimer's

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Aim 1: To determine whether space radiation induces AD-relevant pathological changes in fully differentiated primary hippocampal neurons from CRN8 APP Tg mouse and 3xTg AD mouse models.

Aim 2: To determine whether space radiation induces neurodegeneration and exacerbate AD-relevant pathological/cognitive/behavioral changes in 3xTg AD mice. These proposed studies will specifically addressed many of the critical issues NASA has identified.

Resources (None Listed)

Deliverables (2)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Characterization of impact of space radiation on neurodegeneration and exacerbation of AD-relevant pathological/cognitive/behavioral changes in 3xTg AD mice. Data will provide risk characterization in support of CNS gap 2 closure.

Internal Customers:
None External Customers:
None

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Internal Customers:
None External Customers:
None

Mappings

Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Two-Hit Model of Alzheimer's Disease

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?