Short Title:
Two-Hit Alzheimer's
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
Aim 1: To determine whether space radiation induces AD-relevant pathological changes in fully differentiated primary hippocampal neurons from CRN8 APP Tg mouse and 3xTg AD mouse models.
Aim 2: To determine whether space radiation induces neurodegeneration and exacerbate AD-relevant pathological/cognitive/behavioral changes in 3xTg AD mice. These proposed studies will specifically addressed many of the critical issues NASA has identified.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Characterization of impact of space radiation on neurodegeneration and exacerbation of AD-relevant pathological/cognitive/behavioral changes in 3xTg AD mice. Data will provide risk characterization in support of CNS gap 2 closure.
Internal Customers:
None
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Characterization of impact of space radiation on neurodegeneration and exacerbation of AD-relevant pathological/cognitive/behavioral changes in 3xTg AD mice. Data will provide risk characterization in support of CNS gap 2 closure.
Internal Customers:
None
External Customers:
None