Short Title:
Functional Decline - Alzheimers
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
Comparison of proton, silicon and iron radiation on selected neurophysiological end points in APP/PS1 tg mice will provide valuable information about the risks of space radiation-induced neurodegenerative processes. The functional endpoints will be directly correlated with expression of immunohistochemical markers of neurodegeneration, including amyloid plaque load, synaptic proteins and the presence of neuroinflammatory cytokines. This information can be directly related to risks of AD onset in human subjects.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Characterization of space radiation impacts on neurophysiological endpoints correlated with markers of neurodegeneration. Research will provide risk characterization in support of CNS Gap 2 closure.
Internal Customers:
None
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Characterization of space radiation impacts on neurophysiological endpoints correlated with markers of neurodegeneration. Research will provide risk characterization in support of CNS Gap 2 closure.
Internal Customers:
None
External Customers:
None