HRR - Task - Functional decline in mice with Alzheimer's-type neurodegeneration is accelerated by charge-particle radiation

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Functional decline in mice with Alzheimer's-type neurodegeneration is accelerated by charge-particle radiation (Completed)

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry
Principal Investigator: Vlkolinsky, Roman

Short Title: Functional Decline - Alzheimers

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:
Comparison of proton, silicon and iron radiation on selected neurophysiological end points in APP/PS1 tg mice will provide valuable information about the risks of space radiation-induced neurodegenerative processes. The functional endpoints will be directly correlated with expression of immunohistochemical markers of neurodegeneration, including amyloid plaque load, synaptic proteins and the presence of neuroinflammatory cytokines. This information can be directly related to risks of AD onset in human subjects.

Resources (None Listed)

Deliverables (2)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Characterization of space radiation impacts on neurophysiological endpoints correlated with markers of neurodegeneration. Research will provide risk characterization in support of CNS Gap 2 closure.

Internal Customers:
None External Customers:
None

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Internal Customers:
None External Customers:
None

Mappings

Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Functional decline in mice with Alzheimer's-type neurodegeneration is accelerated by charge-particle radiation

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?