HRR - Task - Molecular Characterization of Long-term Degenerative CNS Risks from Space Radiation

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Molecular Characterization of Long-term Degenerative CNS Risks from Space Radiation (Completed)

Last Published: 07/30/20 02:45:15 PM (Central)

Task Book: Entry
Principal Investigator: Wyrobek, Andrew

Short Title: Long-term Degenerative CNS

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Other:

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Characterize the dose dependence of persistent signaling and cellular defects in the CP and hippocampal zones of neurogenesis of 12C and 56Fe-exposed rats that have persistent deficits in their cognitive function and motor behavior.
Characterize the time course of cellular and signaling defects in the CP of rats irradiated with 56Fe beam and determine the temporal relationship between CP defects and abnormal hippocampal neurogenesis.
Determine whether irradiated animals with defective CP also produce CSF deficient in critical metabolites or proteins that are important for adult neurogenesis, using proteomic, metabolomic, and neurosphere cultures.

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Research will identify the critical molecular changes associated with individual variation in persistent neurocognitive deficits resulting from space radiation exposure. This research will provide risk characterization in support of CNS gap 2 closure.

Internal Customers:
None External Customers:
None

Mappings

Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Molecular Characterization of Long-term Degenerative CNS Risks from Space Radiation

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PRRs (2)

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Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?