Short Title:
Long-term Degenerative CNS
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
- Characterize the dose dependence of persistent signaling and cellular defects in the CP and hippocampal zones of neurogenesis of 12C and 56Fe-exposed rats that have persistent deficits in their cognitive function and motor behavior.
- Characterize the time course of cellular and signaling defects in the CP of rats irradiated with 56Fe beam and determine the temporal relationship between CP defects and abnormal hippocampal neurogenesis.
- Determine whether irradiated animals with defective CP also produce CSF deficient in critical metabolites or proteins that are important for adult neurogenesis, using proteomic, metabolomic, and neurosphere cultures.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research will identify the critical molecular changes associated with individual variation in persistent neurocognitive deficits resulting from space radiation exposure. This research will provide risk characterization in support of CNS gap 2 closure.
Internal Customers:
None
External Customers:
None