HRR - Task - Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment

NASA Logo Human Research Roadmap HRP Exploration Data

Evidence Risks Gaps Tasks Reports

Explore Search

- CBS-BMed3
  - BMed
- CBS-CNS - 2
  - BMed
  - CNS

Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment (Completed)

Last Published: 07/31/19 10:05:33 AM (Central)

Task Book: Entry
Principal Investigator: Britten, Richard

Short Title: Brain Proteome

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Other:

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Aim 1. Identify changes in the neuroproteome that are associated with Hze-induced spatial memory impairments (HISMI) and HZE-induced Attentional Set Shifting Impairments (HIASSI).

Aim 2. Identify proteins that are present in the serum and CSF that are biomarkers of an individual rat¿s susceptibility to HISMI/HIASSI.

Aim 3. Determine the LET-dependency for HISMI and HIASSI, and whether the threshold dose is modified by prior exposure to protons, and if the underlying mechanisms of HISMI and HIASSI is constant irrespective of the LET of the Hze particle.

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Evidence on radiation dose thresholds and quality effects on late behavioral endpoints that will contribute to CNS gap 2 closure by provding data for risk characterization.

Internal Customers:
Space Radiation
External Customers:
None

Mappings

Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure

CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment

Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment

Related Tasks (423)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.