HRR - Task - Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment

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Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment (Completed)

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry
Principal Investigator: Britten, Richard

Short Title: Brain Proteome

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Aim 1. Identify changes in the neuroproteome that are associated with Hze-induced spatial memory impairments (HISMI) and HZE-induced Attentional Set Shifting Impairments (HIASSI).

Aim 2. Identify proteins that are present in the serum and CSF that are biomarkers of an individual rat¿s susceptibility to HISMI/HIASSI.

Aim 3. Determine the LET-dependency for HISMI and HIASSI, and whether the threshold dose is modified by prior exposure to protons, and if the underlying mechanisms of HISMI and HIASSI is constant irrespective of the LET of the Hze particle.

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Evidence on radiation dose thresholds and quality effects on late behavioral endpoints that will contribute to CNS gap 2 closure by provding data for risk characterization.

Internal Customers:
Space Radiation
External Customers:
None

Mappings

Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?