Task Space Radiation Effects on Genomic and Epigenetic Stability: Influence of Radiation Quality and Genetic Predisposition-NNX13AK70G (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: GenEpi Stability
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
This project will develop assays that will provide functional biomarkers for exposure that are also indicators of carcinogenic risk. We will accomplish these objectives by evaluating mice with differing sensitivities to radiation for epigenomic instability as measured by changes in miRNA and DNA methylation profiles following exposure to iron, silicon or oxygen ion radiations. The effect of age on the epigenetic radiation induced response will be evaluated using mice of relatively younger and older ages.
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