Task Defining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Cardio Ox-Platts, Active)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Cardio Ox (Cardiovascular Oxidative Damage)
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

SA 1.  To determine the effects of long-duration spaceflight on measures of oxidative and inflammatory stress.

H1: Levels of inflammatory and oxidative biomarkers will be higher during long duration spaceflight, compared to pre-flight levels, and remain elevated immediately following spaceflight.

SA 2. 
To determine the effects of long-duration spaceflight on measures of arterial structure and function through R+3.

H1:
Arterial function, assessed by flow-mediated dilation, will be impaired following long duration spaceflight through R+3.  Carotid intima-medial thickness will increase in response to long duration spaceflight and will stay increased, although at a subclinical level, throughout recovery.

SA 3. 
To determine how alterations in vascular function and structure correlate with changes in circulating biomarkers of oxidative and inflammatory stress.

H1:
Statistical analysis of these biomarkers and indices of atherosclerosis risk will yield a cadre of potential candidates for predictors of vascular dysfunction and atherosclerosis risk.

SA4
: To monitor vascular status of astronauts for up to five years after the completion of their long-duration space flight mission (surveillance). 

Mappings
RiskRisk of Cardiac Rhythm Problems
You are here!TaskDefining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Cardio Ox-Platts, Active)

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskDefining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Cardio Ox-Platts, Active)

RiskRisk of Inadequate Nutrition
You are here!TaskDefining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Cardio Ox-Platts, Active)