Short Title:
Vascular-bone Coupling and Skeletal Health
Responsible HRP Element:
Human Health Countermeasures
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Collaborating Org(s):
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| National Space Biomedical Research Institute (NSBRI) |
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Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
- Determine the functional and structural consequences of prolonged
weightlessness and space radiation (simulated spaceflight) for bone and skeletal
vasculature in the context of bone cell function and oxidative stress.
- Determine the extent to which an anti-oxidant protects against
weightlessness and space radiation-induced bone loss and vascular dysfunction.
- Determine how space radiation influences later skeletal and vascular
recovery from prolonged weightlessness and the potential of anti-oxidants to
improve or prevent this recovery.
Other Resources
| Other Resources Needed?
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Yes
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Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Mechanism definition and an option to investigate clinically for mitigating the effects of unloading and radiation.
This Task contributes to Osteo 4 by identifying oxidative stress as a mechanism underlying bone loss, investigating its interaction with skeletal unloading and describing the contribution of skeletal vasculature to the skeletal effects in the space radiation environment.
Internal Customers:
None
External Customers:
None