Short Title:
Ames AG EPSCoR
Responsible HRP Element:
Human Health Countermeasures
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Collaborating Org(s):
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| NASA Ames Research Center (ARC) |
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Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
Specific aim 1: To use a hypovolemia model (furosemide infusion) to simulate cardiovascular deconditoning observed after short duration spaceflight and bed rest simulations of space flight.
Specific aim 2: To determine effects of Artificail Gravity (AG) exposure on the orthostatic tolerance limit (OTL) of cardiovascularly deconditioned women and men.
Specific aim 3:To determine mechanisms associated with AG exposure-induced changes in OTL of cardiovascularly deconditioned women and men.
Other Resources
| Other Resources Needed?
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Yes
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Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
This task contributed to gap closure by providing evidence on the effect of 90 minute exposure to artificial gravity (AG) on the subsequent orthostatic tolerance limit (OTL) of hypovolemic (deconditioning similar to space flight) men and women. A single, acute bout of AG exposure prolonged the onset of presyncope by 30% in men and 22% in women by increasing cardiac output and cerebral blood flow. While not required to prevent orthostatic intolerance after spaceflight, short exposures to AG is recommended to maintain stroke volume and brain perfusion during longer spaceflights and/or prior to entry into a gravity (Earth or Mars) environment.
Internal Customers:
Human Health Countermeasures
External Customers:
None