HRR - Task - Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats (Immune Assessment)

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Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats (Immune Assessment) (Completed)

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry Unavailable
Principal Investigator: Crucian, Brian

Short Title: Radiation/Iron: Immune Analysis

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Directed

Aims:
This study is complete, was a tissue sharing activity.

Integration/Unique Aspects: Tissue Sharing

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:

Internal Customers:
None External Customers:
None

Mappings

Risk of Adverse Health Event Due to Altered Immune Response

IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats (Immune Assessment)

Related Tasks (53)

Nutritional Status Assessment: SMO-016E

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

The impact of modeled microgravity and prior radiation exposure on cytomegalovirus reactivation and host immune evasion

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Microbial Risk Assessment and Integration

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Validation of Procedures for Monitoring Crewmember Immune Function (Integrated Immune - SMO 015/SDBI 1900) Completed

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Flight-Induced Changes in Immune Defenses-DSO 498

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Incidence of Latent Virus Shedding During Space Flight-DSO 493

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Space Flight-Induced Reactivation of Latent Epstein-Barr Virus

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Consequences of Long-term Confinement and Hypobaric Hypoxia on Immunity in the Antarctic Concordia Environment (CHOICE)

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	Risk of Adverse Health Event Due to Altered Immune Response

The Effects of Long-Term Exposure to Microgravity on Salivary Markers of Innate Immunity

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Immune Countermeasures Validation - Flight

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Examination of Splenic and Thymic Immune Function in Mice (STS-135 Mouse Tissue Sharing Pilot Study)

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Evaluation of Host-Pathogen Interactions During Exposure to Microgravity Analogues -- ASU Grant

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	Risk of Adverse Health Event Due to Altered Immune Response

Clinical Immunology Study - European Collaboration

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	Risk of Adverse Health Event Due to Altered Immune Response

Space Biochemistry Profile

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	Risk of Adverse Health Event Due to Altered Immune Response

Integrative physiology of VIIP: cardiopulmonary, sleep, and cognitive function assessment during hypercapnic bed rest [Thirty-day CO2 Bedrest/LAURIE]

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	Risk of Adverse Health Event Due to Altered Immune Response

Functional immune alterations, latent Herpesvirus reactivation, physiological stress and clinical incidence onboard the International Space Station

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Immune Clinical Correlations

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	Risk of Adverse Health Event Due to Altered Immune Response

Monitoring the Cellular Immunity by in vitro Delayed Type Hypersensitivity Assay on ISS

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Deep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Consequences of longterm-confinement and hypobaric hypoxia on immunity in the Antarctic Concordia Environment: from observations to mechanisms

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	Risk of Adverse Health Event Due to Altered Immune Response

The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Effects of space flights on the proteome of astronauts' plasma (Rithidech) functional immune

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Functional Immune -DNA damage in the ISS astronaut's lymphocytes and their association with stress-induced immune dysfunction (Honglu Wu) Functional immune

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Functional Immune -The impact of an ISS mission on the anti-viral and functional properties of NK-cells, T-cells, B-cells and dendritic cells (Simpson) Functional immune

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

The impact of long duration spaceflight on the function of B-cells and biomarkers of inflammation (Spielmann)

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	Risk of Adverse Health Event Due to Altered Immune Response

Assessment of Normoxic Coastal Antarctic Winterover as an Analog for Spaceflight Immune Dysregulation

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Pilot Assessment of Stress and Latent Herpesvirus Reactivation at Palmer, Antarctica - Platform for Validation of Immune Countermeasures?

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Varicella Zoster virus shedding after antiviral drug (Valacyclovir) treatment in Antarctic expeditioners

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Exploration Atmosphere Bedrest

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Characterizing the Baselines of Sleep Quality, Cognitive / Operational Performance, Immune Function, and Intracranial Fluids for Deep Space Expeditions

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

MinION Viral Detection

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Awakening endogenous retroviruses with the space environment

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

The Effect of Simulated Space Radiation on the Interaction of the Metabolome, Immune System and Lymphatic Anatomy of the Gastrointestinal Tract

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

The impact of human spaceflight on clonal hematopoiesis

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	Risk of Adverse Health Event Due to Altered Immune Response

Endogenous Retrovirus Activation

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Conditions of Toll like receptors system of the human innate immunity cells during long-term isolations

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Monitoring of Deep Space Physiology via Dry Saliva Sampling - Artemis II

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

The impact of simulated microgravity on the anti-tumor properties of human NK-cells and ?d-T cells in vivo: IL-2 and zoledronic acid therapy as a potential countermeasure

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	Risk of Adverse Health Event Due to Altered Immune Response

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight 2 (HRP Funded)

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Validation of Multisystem Countermeasures Protocol for Spaceflight during Antarctica Winterover @ Palmer Station

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Spaceflight-Induced Immune System Dysregulation and Microgravity-Associated Alterations in Microbial Virulence – Infectious Disease Risk for Astronauts

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Dry Saliva Validation (Lab)

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

CSA Immune Profile

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Exercise training as countermeasure for anti-tumor immune dysregulation due to isolation and confinement stress

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

CBS Behavioral and Physiological Factors Data Mining: Immune/Micro Assessment Capabilities

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Maturation Task - Immune Standards to OCHMO

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Maturation Task - Immune CM to SCLT/HMTA

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Effect of Space Radiation on Innate Immune System Homeostasis Drives Immune and Endothelial Cell Dysfunction and Neurodegeneration

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

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Risk Approach Plans (1)

This task can be found in the following Risk Approach Plans.

Immune Risk Approach plan

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