HRR - Task - Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats (Immune Assessment)

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Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats (Immune Assessment) (Completed)

Last Published: 11/23/20 11:55:12 AM (Central)

Task Book: Entry Unavailable
Principal Investigator: Crucian, Brian

Short Title: Radiation/Iron: Immune Analysis

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Directed

Aims:
This study is complete, was a tissue sharing activity.

Integration/Unique Aspects: Tissue Sharing

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:

Internal Customers:
None External Customers:
None

Mappings

Risk of Adverse Health Event Due to Altered Immune Response

IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats (Immune Assessment)

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Nutritional Status Assessment: SMO-016E

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

The impact of modeled microgravity and prior radiation exposure on cytomegalovirus reactivation and host immune evasion

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	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Microbial Risk Assessment and Integration

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Immune Countermeasures Validation (Analog)

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	Risk of Adverse Health Event Due to Altered Immune Response

Validation of Procedures for Monitoring Crewmember Immune Function (Integrated Immune - SMO 015/SDBI 1900) Completed

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Flight-Induced Changes in Immune Defenses-DSO 498

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Incidence of Latent Virus Shedding During Space Flight-DSO 493

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Space Flight-Induced Reactivation of Latent Epstein-Barr Virus

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Consequences of Long-term Confinement and Hypobaric Hypoxia on Immunity in the Antarctic Concordia Environment (CHOICE)

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The Effects of Long-Term Exposure to Microgravity on Salivary Markers of Innate Immunity

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	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Immune Countermeasures Validation - Flight

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Examination of Splenic and Thymic Immune Function in Mice (STS-135 Mouse Tissue Sharing Pilot Study)

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	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Evaluation of Host-Pathogen Interactions During Exposure to Microgravity Analogues -- ASU Grant

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	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Consequences of longterm-confinement and hypobaric hypoxia on immunity in the Antarctic Concordia Environment: from observations to mechanisms

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	Risk of Adverse Health Event Due to Altered Immune Response

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	Risk of Adverse Health Event Due to Altered Immune Response

DNA damage in the ISS astronaut's lymphocytes and their association with stress-induced immune dysfunction (Honglu Wu) Functional immune

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	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

The impact of an ISS mission on the anti-viral and functional properties of NK-cells, T-cells, B-cells and dendritic cells (Simpson) Functional immune

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	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Immune Countermeasure

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	Risk of Adverse Health Event Due to Altered Immune Response

CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation

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	Risk of Adverse Health Event Due to Altered Immune Response

Exploration Atmosphere Bedrest

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	Risk of Adverse Health Event Due to Altered Immune Response

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	Risk of Adverse Health Event Due to Altered Immune Response

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	Risk of Adverse Health Event Due to Altered Immune Response

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PRRs (1)

This task can be found in the following Paths to Risk Reduction.

Immune Path to Risk Reduction

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