Task Fracture Healing in Haversian Bone under Conditions of Simulated Microgravity (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Fracture Healing - Puttlitz
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
(1) Develop a ground-based, ovine model of bone unloading in order to simulate full weightlessness
(2) Interrogate the effects of a simulated microgravity environment on bone fracture healing using this large animal model
(3) Develop a computational model of weightbearing in ovine bone under different experimental conditions in order to characterize the loads experienced by the fracture site
(4) Develop treadmill protocols that enhance bone fracture healing in the presence of simulated microgravity.

(5) Assess combined effects of ultrasound and loading on fracture healing in large animal model.

Integration/Unique Aspects: Plan to integrate with NSBRI-funded ultrasound study (Qin).