Task High LET Radiation Induced Carcinogenesis: Epigenetic Mechanisms in Mouse Models of Human Cancers-NNX13AK69G (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Mouse model human cancer
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
Using mouse models of human colon and lung cancer developed in the other NASA-funded projects this study will provide epigenetic signatures of these cancers. We will evaluate DNA methylation, changes in histone modifications and altered miRNA expression that affects change in gene expression. The functionality of these epigenetic changes will also be tested by manipulating normal and cancer cell lines in culture. This study will provide functional biomarkers that predict the outcome of long-term health effects of space radiation exposure and elucidate epigenetic mechanisms of cancer processes.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskHigh LET Radiation Induced Carcinogenesis: Epigenetic Mechanisms in Mouse Models of Human Cancers-NNX13AK69G

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskHigh LET Radiation Induced Carcinogenesis: Epigenetic Mechanisms in Mouse Models of Human Cancers-NNX13AK69G

RiskRisk of Radiation Carcinogenesis
You are here!TaskHigh LET Radiation Induced Carcinogenesis: Epigenetic Mechanisms in Mouse Models of Human Cancers-NNX13AK69G