HRR - Task - Evaluation of a sclerostin antibody in mice as a novel promoter of bone formation during spaceflight

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Evaluation of a sclerostin antibody in mice as a novel promoter of bone formation during spaceflight (Completed)

Last Published: 07/29/22 01:33:24 PM (Central)

Task Book: Entry Unavailable
Principal Investigator: Ferguson, Virginia

Short Title: Sclerostin Mice

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

National Space Biomedical Research Institute (NSBRI)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Aim 1: Determine the ability of SclAbII to inhibit diminished bone mass, mechanical properties, and microarchitecture due to microgravity exposure in 9-week old female C57BL/6 mice.

Aim 2: Using these same outcome measures, characterize the effects of microgravity on bone and muscle in mice treated only with the placebo.

Aim 3: Compare skeletal outcomes from mice treated with SclAbII (STS-135), myostatin inhibitor (STS-118), and osteoprotegerin (STS-108).

Aim 4: Facilitate STS-135 tissue collection for investigators in NASA’s biospecimen sharing program.

Resources (None Listed)

Deliverables (1)

Mappings

Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Evaluation of a sclerostin antibody in mice as a novel promoter of bone formation during spaceflight

Risk Of Early Onset Osteoporosis Due To Spaceflight

Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Evaluation of a sclerostin antibody in mice as a novel promoter of bone formation during spaceflight

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.