Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
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Aims:
Aim 1: Determine the ability of SclAbII to inhibit diminished bone mass, mechanical properties, and microarchitecture due to microgravity exposure in 9-week old female C57BL/6 mice.
Aim 2: Using these same outcome measures, characterize the effects of microgravity on bone and muscle in mice treated only with the placebo.
Aim 3: Compare skeletal outcomes from mice treated with SclAbII (STS-135), myostatin inhibitor (STS-118), and osteoprotegerin (STS-108).
Aim 4: Facilitate STS-135 tissue collection for investigators in NASA’s biospecimen sharing program.