Task Molecular mechanisms underlying heart failure and arrhythmias in astronauts (1-year NSBRI Postdoctoral Fellowship) (Molecular Arrhythmias-Gershovich/Werhans, Completed) (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: Molecular Arrhythmias
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

It has been documented that astronauts are susceptible to the development of cardiac arrhythmias and cardiomyopathy.  Since we have identified a defect in cardiac ryanodine receptor (RyR2) associated with both arrhythmias and reduced cardiac contractility in patients with heart failure, we will investigate whether RyR2 dysfunction occurs as a result of external stressors associated with space travel.

 

In aim 1, we will determine the effects of hind limb suspension on cardiac electrophysiological parameters and arrhythmia susceptibility in mice.  Moreover, changes in intracellular calcium release via RyR2 will be assessed in ventricular myocytes isolated from mice subjected to hind limb suspension. 

 

In the second aim, we will determine the effects of protein radiation on the mouse heart.  Electrophysiology studies will be performed during and following radiation to determine whether protein radiation provokes arrhythmogenesis.  Finally, the effects of radiation will be determined on intracellular calcium release via RyR2. 

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