Task Comparative Analysis of Charged Particle-Induced Autosomal Mutagenesis in Murine Tissue and Cells (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Murine Tissue II
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. To use a comparative biology approach and a transgenic mouse model that involves both in vitro and in situ approaches with two cancer development processes, genomic instability and aneuploidy, links them to each other and to specific mechanisms of mutagenesis at an endogenous autosomal locus in epithelial cells.
  2. To define links between the processes that lead to early establishment of genomic instability, aneuploidy, and mechanisms of autosomal mutagenesis found in many kinds of human epithelial cancers.
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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskComparative Analysis of Charged Particle-Induced Autosomal Mutagenesis in Murine Tissue and Cells

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskComparative Analysis of Charged Particle-Induced Autosomal Mutagenesis in Murine Tissue and Cells

RiskRisk of Radiation Carcinogenesis
You are here!TaskComparative Analysis of Charged Particle-Induced Autosomal Mutagenesis in Murine Tissue and Cells