Task Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Postdoctoral Fellowship) (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: Neurobehavioral SR
Responsible HRP Element: Behavioral Health and Performance
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

The present proposal addresses this need via the application of an animal model to determine:

  1. The long-term effects of radiation exposure on cognitive neurobehavioral function and the dopamine neurotransmitter system; and
  2. The effectiveness of flaxseed dietary supplementation to mitigate the neurobehavioral and neurochemical effects of radiation exposure.
  3. To determine DAergic and inflammatory protein levels in radiation-induced, neurobehaviorally impaired Fischer and Lewis rats and in radio-protectant-treated flaxseed rats.
  4. To assess functional changes in dopaminergic neurotransmission following head-only proton radiation using well-characterized dopamine receptor-mediated behaviors (i.e., DA agonist-induced yawning and hypothermia)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
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