Short Title:
Early Arthritis
Responsible HRP Element:
Human Health Countermeasures
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Collaborating Org(s):
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| National Space Biomedical Research Institute (NSBRI) |
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Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
This project’s goal is to investigate the effects of microgravity on
cartilage homeostasis by exposing two chondrocyte cell lines to a modeled
microgravity environment using a rotating wall vessel bioreactor. Cells exposed
to microgravity will be compared to cells incubated under normal gravitational
conditions as a control, as well as an arthritic-like cell model induced by
treating chondrocytes with pro-inflammatory cytokines such as IL-1B and
oncostatin M (OSM). Disruptions in cell-matrix interactions, changes in
cytoskeletal morphology and gene up-regulation will be evaluated to determine
changes in chondrocyte metabolism.
Other Resources
| Other Resources Needed?
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Yes
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Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Report on the mechanisms involved in articular cartilage loss after exposure to microgravity.
This Task contributes to Osteo 4 by investigating the mechanisms for articular cartilage loss, potential biomarkers and countermeasures.
Internal Customers:
Human Health Countermeasures
External Customers:
None