Short Title:
Nervous system & bone loss
Responsible HRP Element:
Human Health Countermeasures
|
Collaborating Org(s):
|
| National Space Biomedical Research Institute (NSBRI) |
|
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
-
To determine if VBX causes bone loss by activation of the sympathetic
nervous system in the VBX model using b-blocker-treated mice and mice
lacking the b2AR globally or specifically in osteoblasts.
- To analyze the bone phenotype of mice devoid of vestibular gravity sensor (Het-/- mice).
- To determine if vestibular stimulation by centrifugation could be
used as a countermeasure to bone loss under microgravity.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
This study will characterize the role of the vestibular system in the maintenance of BMD on Earth and its dysfunction under microgravity.
This Task contributes to Osteo 4 by studying the possible role of the vestibular system as a risk factor for bone loss and Osteo 7 by investigating a novel approach for mitigating bone loss.
Internal Customers:
None
External Customers:
None