Short Title:
CV Data Mining for VIIP
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
The overall aim for this project was to compile and analyze existing multi-system data obtained from astronauts before, during and after space missions to identify and characterize associations between crew who experienced changes in vision and elevated opening CSF pressures compared with those who did not.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
A final report was delivered to the project on 10/3/11. Findings: In this study, it was found that crewmembers in the highest tertile for both systolic and diastolic blood pressure demonstrated less variability in pulse pressure and that the decrease in variability was due in part to lower levels of compliance as indicated by similar or higher levels of total peripheral resistance after compared with before flight levels. Whether there is a relation between blood pressure regulation and total peripheral resistance in crew presenting with negative changes in visual acuity remains unknown. However, using traditional theory, a higher total peripheral resistance combined with lower vascular compliance is generally associated with greater pathological changes to the cardiovascular system and potentially to the surrounding tissues. This information contributed to gap closure by informing the evidence base.
Internal Customers:
None
External Customers:
None