Task Mouse models approach for intestinal tumorigenesis estimates by space radiation (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Mouse Models SR
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Quantitatively compare HZE ion or high-energy proton irradiation to gamma-ray effects on intestinal tumor incidence and grade using the Apc+/min tumor model.
  2. Characterize and compare inactivation of wt APC locus on chromosome 18B1 after gamma vs. HZE ion or high-energy proton irradiation with the Apc+/min tumor model.
  3. Determine intestinal tumor incidence in the Apc+/min; Ppm1d-/- mouse model and mechanisms for reactivation of the Apc+/min tumor phenotype by radiation.
  4. Determine molecular signatures by comparative genomic hybridization (CGH) and expression profiling in spontaneous intestinal tumors compared to those induced by HZE ions, high-energy protons, and gamma irradiation.
  5. Quantitatively compare HZE ion or high-energy proton irradiation vs. gamma-ray effects on incidence of other tumors.
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