Task Mechanisms of Ocular Cataracts (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: Ocular Cataract
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

We investigated the mechanisms of cataractogenesis by looking at radiation cataract formation in animals haploinsufficient for one or more genes involved in DNA damage recognition and repair or cell cycle checkpoint control.

In particular, this project examined the influence of multiple haplo-insufficiencies in the development of high-LET radiation induced opacities in mice heterozygous for Atm, Mrad9 or Brca1. Cataract incidence and progression was quantified longitudinally and compared to that from similarly irradiated wild type animals.

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