Task Computational Modeling Of Chromosome Aberrations Produced By HZE Particles (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Chromosome Modeling
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. For Specific Aim 1, we will replace the current approach of using “obligate” (deterministic) cycles with a more accurate computer-based approach involving cycle probabilities.
  2. For Aim 2, new methods are being developed that allow systematic comparison of apparently incomplete aberrations with corresponding complete aberrations and corresponding truly incomplete ones, even in the case of very complex aberrations. Under Aim 2 we will also consider size distributions of fragments that have one telomere and one unrejoined free end, for comparison to recent data using pan-telomeric probes; and analyze mixtures of different radiations.
  3. Aim 3 will emphasize more realistic computer algorithms for break misrejoining, bringing this aspect of aberration modeling more nearly in line with the very sophisticated models now being used by various groups for assessing the influence of track structure and chromatin geometry on DSB locations.
  4. For Aim 4 we plan to apply a method we previously used for low LET data to data for high LET, including iron ions. The method involves testing frequencies of color junction pairs for deviations from randomness.
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