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Task Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Task Book: Entry
Principal Investigator: Limoli, Charles
Short Title: Induced Genomic
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Space Biology Program
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Elucidate the dose-response relationship for the induction of genomic instability in neural precursor cells cultured in vitro or isolated from mouse brain after exposure to protons and iron ions.
  2. Determine if chronic changes in cellular redox state alter the dose response relationship determined above and predispose neural precursor cells to proton- and iron ion-induced genomic instability.
  3. Determine if differentiation of genomically unstable neural precursor cells is altered in vitro, or if neurogenesis is altered in vivo when unstable precursor cells are implanted into the brains of control or irradiated mice.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
GapCNS - 6: How can new knowledge and data from molecular, cellular, tissue and animal models of late CNS risks or clinical human data be used to estimate late CNS risks to astronauts from GCR and SPE?
You are here!TaskMechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
You are here!TaskMechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant