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Task Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Task Book: Entry
Principal Investigator: Limoli, Charles
Short Title: Induced Genomic
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Space Biology Program
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Elucidate the dose-response relationship for the induction of genomic instability in neural precursor cells cultured in vitro or isolated from mouse brain after exposure to protons and iron ions.
  2. Determine if chronic changes in cellular redox state alter the dose response relationship determined above and predispose neural precursor cells to proton- and iron ion-induced genomic instability.
  3. Determine if differentiation of genomically unstable neural precursor cells is altered in vitro, or if neurogenesis is altered in vivo when unstable precursor cells are implanted into the brains of control or irradiated mice.
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
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