Short Title:
Induced Genomic
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
|
|
Aims:
- Elucidate the dose-response relationship for the induction of genomic instability in neural precursor cells cultured in vitro or isolated from mouse brain after exposure to protons and iron ions.
- Determine if chronic changes in cellular redox state alter the dose response relationship determined above and predispose neural precursor cells to proton- and iron ion-induced genomic instability.
- Determine if differentiation of genomically unstable neural precursor cells is altered in vitro, or if neurogenesis is altered in vivo when unstable precursor cells are implanted into the brains of control or irradiated mice.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research will provide evidence on how alterations in redox state, similar to those observed during spaceflight, impact response of neural precursor cells to space radiation exposure. These data will be used for risk characterization in support CNS Gap 2 closure.
Internal Customers:
None
External Customers:
None