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Task Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Task Book: Entry
Principal Investigator: Raber, Jacob
Short Title: apoE
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
1A. Determine if E isoform is associated with radiation-induced apoptosis of neural precursor cells in the dentate SGZ
1B. Determine the role of E isoform in the development of radiation-induced cognitive deficits and whether the severity of these deficits are associated with apoptosis of neural precursor cells in the dentate SGZ. Mice will be tested 3 months following radiation
1C. Determine how E isoform affects neurogenesis following 56Fe- irradiation, and determine if this effect is related to the severity of radiation-induced cognitive deficits
2A. Determine if the presence of a specific E isoform is associated with markers of oxidative stress following radiation injury
2B. Determine if the antioxidant a-lipoic acid enhances cognitive function and reduces radiation-induced cognitive impairments and whether this ability is E isoform-dependent.
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
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