Short Title:
apoE
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
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Aims:
1A. Determine if E isoform is associated with radiation-induced apoptosis of neural precursor cells in the dentate SGZ
1B. Determine the role of E isoform in the development of radiation-induced cognitive deficits and whether the severity of these deficits are associated with apoptosis of neural precursor cells in the dentate SGZ. Mice will be tested 3 months following radiation
1C. Determine how E isoform affects neurogenesis following 56Fe- irradiation, and determine if this effect is related to the severity of radiation-induced cognitive deficits
2A. Determine if the presence of a specific E isoform is associated with markers of oxidative stress following radiation injury
2B. Determine if the antioxidant a-lipoic acid enhances cognitive function and reduces radiation-induced cognitive impairments and whether this ability is E isoform-dependent.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research will provide evidence on impact of individual sensitivity and antioxidants on acute cognitive decrements following SR exposure, in support of closure of CNS Gap 3.
Internal Customers:
None
External Customers:
None