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Task Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Task Book: Entry
Principal Investigator: Raber, Jacob
Short Title: apoE
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
1A. Determine if E isoform is associated with radiation-induced apoptosis of neural precursor cells in the dentate SGZ
1B. Determine the role of E isoform in the development of radiation-induced cognitive deficits and whether the severity of these deficits are associated with apoptosis of neural precursor cells in the dentate SGZ. Mice will be tested 3 months following radiation
1C. Determine how E isoform affects neurogenesis following 56Fe- irradiation, and determine if this effect is related to the severity of radiation-induced cognitive deficits
2A. Determine if the presence of a specific E isoform is associated with markers of oxidative stress following radiation injury
2B. Determine if the antioxidant a-lipoic acid enhances cognitive function and reduces radiation-induced cognitive impairments and whether this ability is E isoform-dependent.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
GapCBS-CNS - 4: What are the most effective medical or dietary countermeasures to mitigate CNS risks? By what mechanisms are the countermeasures likely to work?
You are here!TaskNeurogenesis and cognition in human apoE transgenic mice following 56Fe radiation
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
GapCBS-CNS - 4: What are the most effective medical or dietary countermeasures to mitigate CNS risks? By what mechanisms are the countermeasures likely to work?
You are here!TaskNeurogenesis and cognition in human apoE transgenic mice following 56Fe radiation