Task Mechanistic and Quantitative Studies of Bystander Reponses in 3-D Human Tissues for Low-Dose Radiation Risk Estimation (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: 3-D Human
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Department of Energy (DoE)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Directed
Aims:

We have previously used the MatTek EPI-200 3D human tissue model in studies of alpha-particle bystander effect. We have now demonstrated a similar bystander effect using low LET proton irradiation of EPI-200 tissue. In our current studies, we have developed a masking approach to shield all of the tissue with the exception of a narrow (25 micron) strip of directly irradiated tissue in the center of the dish. This approach has improved the precision of alignment of the tissues over what was previously achievable with the original microbeam technique.

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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskMechanistic and Quantitative Studies of Bystander Reponses in 3-D Human Tissues for Low-Dose Radiation Risk Estimation

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskMechanistic and Quantitative Studies of Bystander Reponses in 3-D Human Tissues for Low-Dose Radiation Risk Estimation

RiskRisk of Radiation Carcinogenesis
You are here!TaskMechanistic and Quantitative Studies of Bystander Reponses in 3-D Human Tissues for Low-Dose Radiation Risk Estimation