The specific aims of the study were: 

1) to determine effects of maintenance of female subjects in the head-down tilt bed-rest model on functional immune responses. This will be determined by examining the effects of bed-rest on immunization to the innocuous bacteriophage PhiX-174, and on leukocyte proliferation and cytokine production.

2) to determine effects of maintenance of female subjects in the head-down tilt bed-rest model on resistance to infection. This will be determined by examining the effects of bed rest on reactivation of persistent virus infections with which the subjects are already infected, including Epstein-Barr virus and human polyomaviruses.


Integration/Unique Aspects: unknown