Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Radiation Leukemogenesis
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
The goal of this program is to provide information required to develop a rational scientific basis for estimation of risks for leukemogenesis in humans from exposure to radiation during space flight. This will be accomplished using several coordinated research activities. A key activity will be to develop quantitative data on the relative leukemogenic effectiveness of specific HZE particles and of high-energy protons compared with gamma rays in a mouse model of radiation-induced acute myeloid leukemia (AML). Extrapolation of risks from this mouse model to risks in humans requires additional information, and a major component of research activities in this program are designed to provide such information. A major research effort of this program is focused on studies of cellular and molecular mechanisms and processes involved in radiation-induced AML. These studies will not only improve the basic understanding of the pathogenesis of AML but will also provide information on cellular and molecular biomarkers that may be useful in predicting individuals at increased risk. These activities will focus on the use of molecular and molecular cytogenetic approaches, the development of new model systems, and comparative analyses of murine and human AML to facilitate the translation of results obtained in mice to human AMLs. Problems of extrapolation are not limited to biological factors. There are clear dosimetric differences that also must be considered when extrapolating data obtained from mouse studies to human risks. To address these issues this project also has an important physics and dosimetry component that includes modeling of dose to target cells in murine and human bone marrow.
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