Task Echocardiographic Assessment of Cardiovascular Adaptation and Countermeasures in Microgravity (Cardio Adaptation-Thomas, Completed) (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: Cardio Adaption
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Extension of work to calculate two-dimensional myocardial strain, improving sensitivity for detecting preclinical alterations in cardiac function.
  2. To apply 2D strain in graded exercise to detect myocardial dysfunction in its earliest phases, allowing both diagnostic capabilities and a means of judging exercise as a countermeasure.
  3. To continue our ongoing study of the magnitude and predictors of LV mass regression following acute volume and pressure unloading as a ground-based analog for manned spaceflight.
  4. To develop, in collaboration with OBPR Fundamental Physics scientists from Glenn, a sophisticated fluid-structure model of the left ventricle constrained by the pericardium to investigate the impact that microgravity has on unloading the heart by a removal of pericardial constraint.
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