Task Impact of HZE Particles Exposure on Proliferation and Differentiation of Human Neural System Cells (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: HZE Neural
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Determine the impact of 56Fe and gamma-ray irradiation on proliferation and differentiation of K048 cells in vitro.
  2. Determine gene expression patterns and apoptotic responses of proliferating and differentiating K048 cells following 56Fe and gamma-ray irradiation.
  3. Determine whether in vitro primed K048 cells can differentiate into neurons when grafted into neurogenic and non-neurogenic regions of rat brains damaged by 56Fe and gamma-rays.
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