Task HZE Radiation: Modulation Of Genetic Effects By RNA Interference Of NHEJ (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: HZE RNA
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
Our general aim in this proposal is to examine connections between cellular radiosensitivity phenotypes relevant for carcinogenesis, namely chromosome aberration formation, mutagenesis and telomere fusions, and deficiencies in various components of the non-homologous end joining system, using RNA interference to systematically knockdown gene products known to be involved, either singly or in combination.
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