Task Early Detection of Inflammatory Response and the Subsequent Health Outcomes Due to High LET Particle Radiation: An Integrated Metabolomics Study (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Metabolomics
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. We will perform an integrated NMR and LC-MS metabolomics study of the impact of exposing mice and rats to 0, 0.5, and 3 Gy using both high LET proton and iron ion radiation. The metabolic perturbations in global physiology and the subsequent health outcomes will be investigated from 1 day to 1 year post irradiation using key body fluids and excised tissues.
  2. In parallel, we will investigate the impact of exposing mice and rats to gamma-rays at low and high doses to determine the differences in dose-dependent effects between proton, iron ions and gamma-rays.
  3. Furthermore, histopathologic analysis and basic-translational cell and molecular investigations will be used to link metabolic "signatures" and disease pathogenesis.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskEarly Detection of Inflammatory Response and the Subsequent Health Outcomes Due to High LET Particle Radiation: An Integrated Metabolomics Study

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskEarly Detection of Inflammatory Response and the Subsequent Health Outcomes Due to High LET Particle Radiation: An Integrated Metabolomics Study

RiskRisk of Radiation Carcinogenesis
You are here!TaskEarly Detection of Inflammatory Response and the Subsequent Health Outcomes Due to High LET Particle Radiation: An Integrated Metabolomics Study