Short Title:
HZE Neuroinflammation
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
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Aims:
- In our first aim we will endeavor to use a sufficient dose range in order to compare outcomes with the physiologic and pathologic endpoints established in our current data using gamma radiation.
- In our second aim, we will use specific inhibitors of cyclooxygenase-2 to determine if prostaglandins play a key role in the neuroinflammatory response to HZE particles.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research to test efficacy of a biological countermeasure on mitigation of neuroinflammation associated with long term cognitive impairment following radiation exposure, in support of CNS Gap 4 closure.
Internal Customers:
None
External Customers:
None