Task Human Cerebral Vascular Autoregulation and Venous Outflow in Response to Microgravity-Induced Cephalad Fluid Redistribution (Roberts)
Last Published:  04/20/22 11:43:24 AM (Central)
Short Title: Cephalad Fluid Redistribution
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
In order to fully characterize intracranial adaptation to long-term microgravity, we will use magnetic resonance imaging (MRI) which is the terrestrial gold standard. MRI allows direct visualization and functional characterization of the intracranial contents. Indeed, MR imaging is the clinical standard of care in evaluating patients with idiopathic intracranial hypertension. We will use a suite of advanced MRI sequences in conjunction with gadolinium contrast and a CO2 challenge to: 1) characterize weightlessness-induced intracranial compartmental fluid volume changes at the macroscopic (brain, CSF), microscopic (brain tissue water) and vascular (venous) levels following adaptation to long-term spaceflight and 2) assess for potential resultant hemodynamic changes (cerebral perfusion) in the brain. This proposal represents the most relevant and advanced suit of MRI techniques for the characterization of intracranial compartmental fluid and hemodynamic changes induced by long-term microgravity. The specific sequences will be carried out by the recognized experts in each area and in most cases, the developer of the specific technique.