Task Targeting NO/IKK Signaling to Counteract Hemodynamic Flow-Dependent Endothelial Dysfunction and Vascular Damage after Space Radiation (Endothelial Dysfunction SR-Natarajan, Active) (Completed)
Last Published:  07/29/22 01:33:24 PM (Central)
Short Title: Endothelial Dysfunction SR
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
The objectives are: (i) to investigate the significance of high LET radiation on causing endothelial dysfunction and associated damages on vascular bed, impairment of cell migration/motility and inhibition of vascular healing processes. Three different HZE ion beams (16O, 28Si, and 56Fe) accelerated to the same velocity (600 MeV/amu) and having similar track structure dimensions, but different ionization densities will be compared; (ii) to study how high LET radiation concurrently exploits eNOS, Hsp-90, and IKK# signaling to cause endothelial dysfunction, while impairing the repair capacity of bone-marrow derived endothelial progenitor cells (EPCs); and (iii) to examine whether the findings, whilst allowing us to gain knowledge on the mechanism of cardiovascular alterations by high LET radiation exposure, would lead us to develop and quantitatively assess biological countermeasures for cardiovascular risks.

This study emphasizes a multi-stage approach (in vitro, ex vivo and in vivo) to understand the underlying mechanism of functional alteration of flow-adapted endothelial cells in response to space radiation.
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