Task Non-Invasive Monitoring of Intracranial Pressure (ICP) with Volumetric Ophthalmic Ultrasound [ULTRASOUND ICP/DENTINGER] (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Short Title: Ultrasound ICP
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Exploration Medical Capability (ExMC) Element
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
1. Develop a volumetric ultrasound ophthalmic imaging system with improved image quality providing user independent, 3D imaging of the full ocular anatomy for pre-flight scans, postflight scans, and in-flight scans with minimal crew time and ground guidance during image capture.

2. Enable multimodality volume registration of in-flight ultrasound and pre-flight magnetic resonance (MR) ophthalmic scans enabling the ability to longitudinally track structural alterations in response to microgravity and correlate these ocular structural changes with elevated ICP and visual acuity changes.

3. Non-invasively monitor the ICP based on reliable measurements of the optic nerve sheath diameter and posterior globe flattening determined from volumetric ultrasound scan scans performed by non-expert operators with minimal image capture time required.

4. Non-invasively observe intracranial dynamics through measurement of the pulsation in the retinal blood flow and the optic nerve sheath from ultrasound image sequences and demonstrate the interaction between ICP and cerebral hemodynamics as they relate to cerebrospinal compensatory reserve.

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