Short Title:
Digital Astronaut: Bone Remodeling Model
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
To develop and implement a bone adaptation model to inform work led by the Bone Discipline Lead to determine if changes in bone density and architecture changes due to long-duration spaceflight adversely impact long-term health risk. More specifically, this work will inform the QCT ORID study (MTL 729, Sibonga PI) to help answer the following questions:
1. What is the time-course change/recovery of BMD and bone strength during and after spaceflight mission, with and without exercise countermeasure?
a. Skeletal loading along with endocrine regulation and local biochemical mediators are what drives the physiological mechanism of bone remodeling to maintain bone.
b. Exercise induced loading, with appropriate input to a model can approximately predict the effect of specific exercise prescription and thus help to evaluate its benefits as a countermeasure option.
2. What other measures of bone contribute to bone strength independent of BMD (Bone Quality)?
a. One effort is underway to evaluate Finite Element (FE) estimates of bone strength (bone fracture loads) as a potential standard for bone health.
b. A bone remodeling formulation that quantifies dynamic changes in bone has the potential of tracking changes in volume fractions that can relate to QCT BMD and ash density estimates, upon which FE bone strength is based. In addition coupling a bone remodeling model with a QCT based FE model may also provide geometry changes.
3. Is the potential for long-term adverse bone health risk to astronauts influenced by multiple flights?
Integration/Unique Aspects: Coordination between Digital Astronaut and Bone Discipline
Other Resources
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Yes
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Category:
Technology or Tool
Subcategory:
Computational Models or Simulations
Description:
• Bone adaptation g model for site specific analyses (hip and spine) of vBMD changes to be used in conjunction with finite element models for predictive simulations of bone strength changes for known or estimated pre-, during, and post-flight conditions.
• Provide support for simulation analyses and results interpretation to help quantify the effects of in-flight exercise countermeasures on sub-regions of the hip and spine bone
• Model description documents and analysis reports to accompany the above deliverables
• Contribution to gap closure: The model and simulation results will be used to provide additional information that will help answer the questions listed above to close gaps Fracture 3 and Osteo 4.
Internal Customers:
None
External Customers:
None