Task Impact of Age, Genetics Variants and High LET Track Structure on Mammary Cancer Risk Estimates (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Age Mammary Cancer
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

To formulate better risk estimates, key data is needed including how age, genetic susceptibility and radiation quality affect carcinogenic potential in irradiation sensitive tissues.


AIM 1: Test that early phosphorylation signals are uniquely different after high vs low-LET radiation exposure, and between different cell types of the same tissue of origin.

 

AIM 2:To test whether potential of carcinogenesis risk assessed by centrosome abnormalities, telomere length changes, and late phosphorylation profiles differ between high and low-LET exposures and between different cell types.

 

AIM 3: To test that phosphorylation patterns and carcinogenic risk will differ on whether primary exposure is due to direct hit by HZE nuclei vs delta-ray traversal.

Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskImpact of Age, Genetics Variants and High LET Track Structure on Mammary Cancer Risk Estimates

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskImpact of Age, Genetics Variants and High LET Track Structure on Mammary Cancer Risk Estimates

RiskRisk of Radiation Carcinogenesis
You are here!TaskImpact of Age, Genetics Variants and High LET Track Structure on Mammary Cancer Risk Estimates