Task Charged Particle Effects on Neuronal Injury, Plasticity and Neurodegeneration (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: Plasticity and Neurodegeneration
Responsible HRP Element: Space Radiation
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Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
To address the foregoing problems we will measure the impact of charged particle irradiation on neuronal anatomy and function using cultures of human neurons grown in the presence and absence of additional cell types known to be critical for proper neuronal function. Studies will also be performed in the presence of antioxidants that can minimize damage from reactive species, providing a useful strategy for gauging the importance of radiation-induced oxidative stress. These cell-based studies will be complemented by animal studies in which similar endpoints will be measured in brain tissue isolated from irradiated mice. One animal model genetically modified to express a neuronal fluorescent marker will be used to measure the subtle structural changes to neurons after irradiation. Another animal model genetically modified to exhibit early onset dementia will be used to gauge how exposure to charged particles found in space might impact the onset and/or severity of neurodegenerative phenotypes.
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