Task A Systems Analysis of Progression-Phase Determinants of Radiation-Induced Carcinogenesis and its Modulation by Stem Cells (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Cancer Progression and Stem Cells
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

The goal of our investigation is to provide multi-scale data for an improved mechanistic understanding, and an augmented conceptual framework for NASA's use in estimation of carcinogenesis risk from space radiation.


Aim 1) Investigate the radiation modulation of the angiogenesis and migration/invasion bottlenecks – molecular characterization and mechanistic elucidation.

 

Aim 2) Elucidate the role of mesenchymal stem cells in modulation of the ‘cancer progression hallmarks’ following the radiation exposures under study in Aim 1.

 

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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskA Systems Analysis of Progression-Phase Determinants of Radiation-Induced Carcinogenesis and its Modulation by Stem Cells

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskA Systems Analysis of Progression-Phase Determinants of Radiation-Induced Carcinogenesis and its Modulation by Stem Cells

RiskRisk of Radiation Carcinogenesis
You are here!TaskA Systems Analysis of Progression-Phase Determinants of Radiation-Induced Carcinogenesis and its Modulation by Stem Cells